717-57-7Relevant articles and documents
Metal-free oxidative synthesis of benzimidazole compounds by dehydrogenative coupling of diamines and alcohols
Gao, Hu,Hu, Jiaming,Li, Mengjia,Sun, Jinnan,Wan, Jing,Zhang, Feng,Zhang, Zhibing
, p. 2852 - 2856 (2022/04/12)
We report a novel metal-free synthesis of benzimidazole compounds by dehydrogenative coupling of diamines and alcohols. Using NHPI as a nonmetallic catalyst combined with molecular oxygen or air as the oxidant, this transformation represents a widely applicable protocol to N-heterocycles, such as benzimidazoles, benzothiophenes, benzooxazoles and quinazolines. Flow microreactors operating under optimized conditions enabled this reaction with higher efficiency, and the total residence time was 30 min compared with the batch bubbling reactor (10 h). Moreover, a possible reaction mechanism is proposed according to the control experiments.
Three-Way Chemoselectivity Switching through Coupled Equilibria
Puangsamlee, Thamon,Miljani?, Ognjen ?.
supporting information, p. 5900 - 5904 (2020/08/05)
Controlling the chemoselectivity of reactions operating on complex mixtures, including those found in biological and petrochemical feedstocks or in the primordial soup from which life emerged, is generally challenging. The selectivity of imine oxidation c
Chemoselective aerobic oxidation of 2-amino-N-benzylanilines into N-(2-aminophenyl)imines via a nitroxide-free copper catalysis
Zhai, Yadong,Rong, Jing,Zhang, Zhicheng,Cao, Xiang,Su, Zhenni,Zhou, Qingfa,Tao, Chuanzhou
, p. 1139 - 1142 (2019/03/21)
Chemoselective oxidative synthesis of N-(2-aminophenyl)imines from 2-amino-N-benzylanilines was accomplished through combined use of O2(air) and copper salt. This transformation was performed at room temperature, and the mild oxidation was efficient and chemoselective without using nitroxyl radicals and ligands.
