71636-61-8 Usage
Description
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE, also known as (±)-6-Chloro-PB hydrobromide, is a chemical compound with a complex structure derived from the benzazepine family. It is characterized by its chloro and hydroxy functional groups, as well as its phenyl ring. (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE has been found to have significant applications in the field of neuroscience, particularly in the study of dopamine receptors and their role in various cognitive functions.
Uses
Used in Neuroscience Research:
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE is used as a dopamine D1 receptor (Drd1a) agonist for studying the role of the drd1a-dopamine receptor in the inactivation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. This application helps researchers understand the underlying mechanisms of dopamine receptor signaling and its impact on neuronal function.
Used in Behavioral Studies:
In the field of behavioral neuroscience, (±)-6-Chloro-PB hydrobromide is used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in the Barnes maze in rats. This application aids in understanding the cognitive effects of dopamine receptor activation and its potential implications for the development of therapeutic strategies for cognitive disorders.
Used in Pharmaceutical Development:
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE may also be used in the development of new pharmaceuticals targeting dopamine receptors. Its agonistic properties can be exploited to design drugs that modulate dopaminergic signaling, potentially leading to treatments for various neurological and psychiatric disorders, such as Parkinson's disease, schizophrenia, and attention deficit hyperactivity disorder (ADHD).
Used in Drug Delivery Systems:
Similar to gallotannin, (±)-6-Chloro-PB hydrobromide could potentially be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound's delivery, efficacy, and targeting to specific cellular receptors can be improved, leading to more effective treatments for related conditions.
Biological Activity
Dopamine D 1 -like receptor agonist. Centrally active following systemic administration in vivo .
Biochem/physiol Actions
(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.
Check Digit Verification of cas no
The CAS Registry Mumber 71636-61-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,6,3 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71636-61:
(7*7)+(6*1)+(5*6)+(4*3)+(3*6)+(2*6)+(1*1)=128
128 % 10 = 8
So 71636-61-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H
