71657-88-0Relevant articles and documents
Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes
Nakamura, Shuichi,Tokunaga, Akari,Saito, Hikari,Kondo, Masaru
, p. 5391 - 5394 (2019)
The enantioselective conjugate addition reaction of an α,α-dithioacetonitrile with nitroalkenes was catalysed by chiral bis(imidazoline)-palladium pincer-type complexes. The reaction was applicable to various nitroalkenes to afford products in good yield with high enantioselectivity. The obtained products can be converted to γ-lactam and biologically active rolipram.
Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors
Hilton-Proctor, J. P.,Ilyichova, O.,Jennings, I. G.,Johnstone, R. W.,Mountford, S. J.,Scanlon, M. J.,Shortt, J.,Thompson, P. E.,Zheng, Z.
, (2020/03/03)
N-Methylpyrrolidone is one of several chemotypes that have been described as a mimetic of acetyl-lysine in the development of bromodomain inhibitors. In this paper, we describe the synthesis of a 4-phenyl substituted analogue – 1-methyl-4-phenylpyrrolidin-2-one – and the use of aryl substitution reactions as a divergent route for derivatives. Ultimately, this has led to structurally complex, chiral compounds with progressively improved affinity as inhibitors of bromodomain-containing protein 4.
COMPOUND, MANUFACTURING METHOD OF COMPOUND THROUGH ASYMMETRIC MICHAEL ADDITION USING THE COMPOUND AND MANUFACTURING METHOD OF PHENIBUT USING THE COMPOUND
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, (2018/05/16)
The present invention relates to a compound, a method of producing compounds through an asymmetric Michael addition reaction by using the same, and a method of producing a phenibut compound. Specifically, the compound of the present invention is represented by chemical formula 1. In the chemical formula 1: L represents #AAA# or #BBB# (wherein X represents sulfur or oxygen); R_1 represents hydrogen, an alkyl group having 1-5 carbons, an aryl group having 6-12 carbon atoms, or a benzyl group; R_2 represents an aryl group having 6-12 carbon atoms; R_3 represents hydrogen or an aryl group having 1-12 carbon atoms; and hydrogen in R_1, R_2, and R_3 may be each independently substituted by an alkyl group having 1-5 carbon atoms.COPYRIGHT KIPO 2018