7188-89-8

Basic information

• Product Name: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE
• Synonyms: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE
• CAS NO: 7188-89-8
• Molecular Formula: C₁₆H₁₄N₂
• Molecular Weight: 234.3
• Mol File: 7188-89-8.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE(7188-89-8)
• EPA Substance Registry System: 5-METHYL-1,3-DIPHENYL-1H-PYRAZOLE(7188-89-8)

Safety Data

• Hazardous Substances Data: 7188-89-8(Hazardous Substances Data)

Upstream product

• 75624-85-0 (1,3-Diphenyl-5-pyrazolylmethyl)triphenylphosphonium-chlorid 
• 77252-92-7 (Z)-3-Ethoxy-1-phenyl-but-2-en-1-one 
• 100-63-0 phenylhydrazine 
• 93-91-4 1-phenylbutan-1,3-dione 
• 28691-72-7 (E)-1-propenyl phenyl sulfone 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 67652-99-7 (+/-)_S-(E)-1-(phenylsulfinyl)prop-1-ene 
• 557-98-2 2-chloropropene 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 15409-48-0 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid 
• 59-88-1 phenylhydrazine hydrochloride 
• 95514-24-2 (Z)-1-amino-1-phenyl-1-buten-3-one 
• 574-61-8 benzophenone N-phenylhydrazone 
• 3347-62-4 5-methyl-3-phenyl-1H-pyrazole 

Downstream Products

• 16492-49-2 5-methyl-1,3-diphenyl-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

Regiocontrolled Coupling of Alkynes and Dipolar Reagents: Iron-Mediated [3 + 2] Cycloadditions Revisited

Cyclopentadienyliron dicarbonyl based allenyliron complexes were prepared, and their formal [3 + 2] cycloaddition with a number of dipolar reagents was investigated as a means of preparing heterocyclic compounds in a regiocontrolled manner. In addition, the mechanism of the isomerization of an allenyliron complex to its propargyliron tautomer was investigated. Results in support of both radical and two-electron mechanisms for isomerization are presented.

Copper-Catalyzed Aerobic Cyclization of β,γ-Unsaturated Hydrazones with Concomitant CC Bond Cleavage

A Cu-catalyzed aerobic oxidative cyclization of β,γ-unsaturated hydrazones for the preparation of pyrazole derivatives has been developed. The hydrazonyl radical promoted the cyclization, along with a concomitant CC bond cleavage of β,γ-unsaturated hydrazones. This process has been verified via several control experiments, including a radical-trapping study, an 18O-labeling method, and the identification of the possible byproducts. The advantages of this reaction include operational simplicity, a broad reaction scope, and a mild selective reaction process.

Facile synthesis of pyrazoles by iron-catalyzed regioselective cyclization of hydrazone and 1,2-diol under ligand-free conditions

A facile synthesis of pyrazoles by the cyclization of hydrazones and 1,2-diols was described. In the presence of ferric nitrate, the reaction occurs under neat conditions and makes the use of potassium persulfate to oxidize the diol to α-hydroxy carbaldehyde for the reaction with hydrazones to produce 1,3- and 1,3,5-substituted pyrazoles selectively. The overall regioselective transformation occurs in one-pot under ligand-free, mild conditions even in the presence of air.