7200-18-2

Basic information

• Product Name: N-benzoyl-L-phenylalanine ethyl ester
• Synonyms: (S)-ethyl 2-benzaMido-3-phenylpropanoate;N-benzoyl-L-phenylalanine ethyl ester;(S)-ethyl N-benzoyl-phenylalaninate
• CAS NO: 7200-18-2
• Molecular Formula: C₁₈H₁₉NO₃
• Molecular Weight: 297.34836
• Mol File: 7200-18-2.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzoyl-L-phenylalanine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-L-phenylalanine ethyl ester(7200-18-2)
• EPA Substance Registry System: N-benzoyl-L-phenylalanine ethyl ester(7200-18-2)

Safety Data

• Hazardous Substances Data: 7200-18-2(Hazardous Substances Data)

Usage

General Description

N-benzoyl-L-phenylalanine ethyl ester is a chemical compound that is commonly used as a building block in the synthesis of various pharmaceuticals and other fine chemicals. It is an ester derivative of N-benzoyl-L-phenylalanine, an amino acid that is commonly found in proteins. N-benzoyl-L-phenylalanine ethyl ester is known for its potential therapeutic properties and is often used in the development of new drugs. It is also used as a reagent in organic synthesis and is employed in the preparation of peptide and protein derivatives. N-benzoyl-L-phenylalanine ethyl ester is a valuable and versatile chemical that has various applications in the pharmaceutical and chemical industries.

Upstream product

• 64-17-5 ethanol 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 26348-46-9 (Z)-ethyl 2-benzamido-3-phenylacrylate 
• 3182-93-2 (L)-phenylalanine ethyl ester hydrochloride 
• 98-88-4 benzoyl chloride 
• 5874-61-3 4-benzyl-2-phenyl-2-oxazolin-5-one 
• 945986-05-0 2-benzoylamino-2-benzylmalonic acid monoethyl ester 
• 952524-02-6 (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole 
• 1795-96-6 phenylalanine ethyl ester 
• 945986-15-2 C₂₁H₂₃NO₅ 
• 96-86-6 diethyl benzamidomalonate 
• 100-44-7 benzyl chloride 
• 3081-24-1 H-Phe-OEt 
• 63-91-2 L-phenylalanine 

Downstream Products

• 23912-50-7 (S)-N-(1-Hydrazineyl-1-oxo-3-phenylpropan-2-yl)benzamide 
• 64-17-5 ethanol 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 89311-20-6 N-thiobenzoyl S-phenylalanine ethyl ester 
• 88406-47-7 N-[(S)-1-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-2-phenyl-ethyl]-benzamide 
• 118474-25-2 (S)-Bz-Phe-(S)-LeuOMe 
• 1350524-96-7 1-(2-benzamido-3-phenylpropanoyl)-4-phenylthiosemicarbazide 
• 5267-65-2 (S)-N-(1-hydroxy-3-phenylpropan-2-yl)benzamide 
• 511286-63-8 (4S) 3,4-dibenzyl[1,2,3]oxathiazolidine-2,2-dioxide 
• 1349191-55-4 (S)-ethyl-5-(benzylamino)-6-phenyl-hex-2-ynoate 

Relevant articles and documents

Cobalt-Catalyzed C(sp2)-H Carbonylation of Amino Acids Using Picolinamide as a Traceless Directing Group

Herein we report an efficient protocol for the C(sp2)-H carbonylation of amino acid derivatives based on an inexpensive cobalt(II) salt catalyst. Carbonylation was accomplished using picolinamide as a traceless directing group, CO (1 atm) as the carbonyl

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages

The construction of amide bonds and peptide linkages is one of the most fundamental transformations in all life processes and organic synthesis. The synthesis of structurally ubiquitous amide motifs is essential in the assembly of numerous important molecules such as peptides, proteins, alkaloids, pharmaceutical agents, polymers, ligands and agrochemicals. A method of SO2F2-mediated direct clickable coupling of carboxylic acids with amines was developed for the synthesis of a broad scope of amides in a simple, mild, highly efficient, robust and practical manner (>110 examples, >90% yields in most cases). The direct click reactions of acids and amines on a gram scale are also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

Dynamic Kinetic Resolution of Azlactones by a Chiral N, N-Dimethyl-4-aminopyridine Derivative Containing a 1,1′-Binaphthyl Unit: Importance of Amide Groups

A dynamic kinetic resolution (DKR) of azlactones in the presence of benzoic acid and a binaphthyl-based N,N-4-dimethylaminopyridine (DMAP) derivative 1i having two amide groups at the 3,3′-positions of a binaphthyl unit is developed. The reaction proceeded smoothly with a wide range of azlactones to provide α-amino acid derivatives with good to high enantiomeric ratios (er's). A multigram-scale reaction (2.5 g) for the DKR of azlactone 2d was also demonstrated, and the resulting product was converted to unnatural α-amino acid 6d′.