72090-97-2

Basic information

• Product Name: 1H-Pyrrole-3,4-dicarboxylic acid, 2,5-dihydro-1-methyl-2-phenyl-, dimethyl ester
• CAS NO: 72090-97-2
• Molecular Formula: C15H17NO4
• Molecular Weight: 275.304
• Mol File: 72090-97-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3,4-dicarboxylic acid, 2,5-dihydro-1-methyl-2-phenyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3,4-dicarboxylic acid, 2,5-dihydro-1-methyl-2-phenyl-, dimethyl ester(72090-97-2)
• EPA Substance Registry System: 1H-Pyrrole-3,4-dicarboxylic acid, 2,5-dihydro-1-methyl-2-phenyl-, dimethyl ester(72090-97-2)

Safety Data

• Hazardous Substances Data: 72090-97-2(Hazardous Substances Data)

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 104156-73-2 Trifluoro-methanesulfonatemethyl-[1-phenyl-meth-(Z)-ylidene]-trimethylsilanylmethyl-ammonium; 
• 90606-10-3 (E)-N-(phenylmethylene)-1-(trimethylsilyl)methylamine 
• 100-52-7 benzaldehyde 
• 622-29-7 N-Benzylidenemethylamine 

Downstream Products

• 104156-41-4 1-methyl-2-phenyl-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline 
• 104156-40-3 1-methyl-2-phenyl-3,4-bis(hydroxymethyl)-3-pyrroline 

Relevant articles and documents

Synthesis and Antineoplastic Activity of Bisoxy>methyl>-Substituted 3-Pyrrolines as Prodrugs of Tumor Inhibitory Pyrrole Bis(carbamates)

A series of bispyrrolines 2-4 were synthesized from either the appropriate α-silylated iminium salt, or an aziridine, or a 2H-azirine in a sequence involving 1,3-dipolar cycloaddition reactions.The antineoplastic activities of the pyrrolines were compared to the corresponding pyrroles.The C-2 gem-dimethyl-substituted pyrroline, 4, which cannot be converted to the pyrrole in vivo, was inactive.The activity of the 2-phenyl-substituted pyrrolines 3 was markedly dependent on the nature of the phenyl substituent, although the correspondingphenylpyrroles all showed comparable activity.The differences in the activities of the pyrrolines 3 may be due to the rate of metabolic conversion of the pyrroline to the pyrrole.Electron-withdrawing substituents on the phenyl ring appear to retard this process.