721-63-1

Basic information

• Product Name: ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE
• Synonyms: ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE;(4-TRIFLUOROMETHYL-PHENYL)-ACETIC ACID ETHYL ESTER;ethyl 2-(4-(trifluoromethyl)phenyl)acetate;REF DUPL: Ethyl 4-(trifluoromethyl)phenylacetate;4-(Trifluoromethyl)benzeneacetic acid ethyl ester;2-[4-(trifluoroMethyl)phenyl]butanoate;Benzeneacetic acid, 4-(trifluoroMethyl)-, ethyl ester;Ethyl 4-(trifluoromethyl)benzeneacetate
• CAS NO: 721-63-1
• Molecular Formula: C₁₁H₁₁F₃O₂
• Molecular Weight: 232.2
• Mol File: 721-63-1.mol
• Article Data: 30

Chemical Properties

• Melting Point: 34-35 °C
• Boiling Point: 239.567 °C at 760 mmHg
• Flash Point: 73.897 °C
• Appearance: Colorless/Solid
• Density: 1.207
• Vapor Pressure: 0.04mmHg at 25°C
• Refractive Index: 1.452
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE(721-63-1)
• EPA Substance Registry System: ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE(721-63-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 721-63-1(Hazardous Substances Data)

Usage

General Description

ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE is an organic compound with the chemical formula C11H11F3O2. It is a colorless liquid with a fruity odor, commonly used as a fragrance ingredient in perfumes and cosmetics. This chemical is also used in the production of pharmaceuticals and agrochemicals, as well as in the synthesis of other organic compounds. ETHYL 4-(TRIFLUOROMETHYL)PHENYL ACETATE is considered to be relatively stable and has low toxicity, making it safe for use in various applications. Additionally, it has a wide range of potential industrial and research applications due to its unique chemical and physical properties.

InChI:InChI=1/C11H11F3O2/c1-2-16-10(15)7-8-3-5-9(6-4-8)11(12,13)14/h3-6H,2,7H2,1H3

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 105-53-3 diethyl malonate 
• 66504-19-6 ethyl α-bromo-(4-trifluoromethylphenyl)acetate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 105-36-2 ethyl bromoacetate 
• 7664-93-9 sulfuric acid 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 
• 64-17-5 ethanol 
• 74426-51-0 4-(trifluoromethyl)phenylacetyl chloride 
• 6148-64-7 ethyl potassium malonate 
• 98-56-6 4-chlorobenzotrifluoride 
• 78950-29-5 4-(trifluoromethyl)phenyl acetate 
• 623-33-6 glycine ethyl ester hydrochloride 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 66504-19-6 ethyl α-bromo-(4-trifluoromethylphenyl)acetate 
• 949141-90-6 6-(4-dimethylaminophenyl)-3-(4-trifluoromethylphenyl)-4-phenyl-α-pyrone 
• 949141-87-1 6-(4-methoxyphenyl)-3-(4-trifluoromethylphenyl)-4-phenyl-α-pyrone 
• 880348-57-2 ethyl 2-(4-(trifluoromethyl)phenyl)acrylate 
• 476429-18-2 methyl 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoate 
• 473706-07-9 4-(4-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid 
• 146533-53-1 1,3-diethyl 2-(4-(trifluoromethyl)phenyl)propanedioate 
• 864878-71-7 2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-ol 
• 1417408-08-2 ethyl 2-(2-nitrophenyl)-2-(4-(trifluoromethyl)phenyl)propanoate 
• 1417408-22-0 2-(2-nitrophenyl)-2-(4-(trifluoromethyl)phenyl)propan-1-ol 
• 1417408-39-9 C₁₈H₁₈F₃NO₃ 
• 1417407-78-3 1-azido-2-(1-ethoxy-2-(4-(trifluoromethyl)phenyl)propan-2-yl)benzene 
• 1417408-05-9 ethyl 2-(2-nitrophenyl)-2-(4-(trifluoromethyl)phenyl)acetate 

Relevant articles and documents

Photoassisted Cross-Coupling Reaction of α-Chlorocarbonyl Compounds with Arylboronic Acids

A Suzuki-Miyaura cross-coupling reaction of α-chloroacetates or α-chloroacetamides with arylboronic acids is made possible by visible-light irradiation. This reaction provides a useful method for the synthesis of α-arylacetates and α-arylacetamides from chlorides under mild reaction conditions. An indole-3-acetic acid derivative that is the key intermediate of the plant hormone auxin can be synthesized from 1-Boc-indole in two steps by combining an iridium-catalyzed C-H borylation and a palladium-catalyzed cross-coupling reaction.

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.

Preparation of Organic Nitrates from Aryldiazoacetates and Fe(NO3)3·9H2O

A thermal protocol is reported for the formal insertion of nitric acid into aryldiazoacetates using Fe(NO3)3·9H2O. This strategy is mild and high yielding and allows the preparation of a large variety of members of an unprecedented family of organic nitrates. The nitrate group can be also readily transformed into other functional groups and heterocyclic moieties and can possibly allow new biological explorations of untapped potential associated with their NO-releasing ability.