72152-84-2

Basic information

• Product Name: 2,6,6-Trimethylcyclohexa-1,3-dien-1-ylcarbonitrile
• Synonyms: 2,6,6-Trimethyl-1,3-cyclohexadiene-1-carbonitrile
• CAS NO: 72152-84-2
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• Product Categories: Miscellaneous Reagents
• Mol File: 72152-84-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 227.4°C at 760 mmHg
• Flash Point: 91.2°C
• Appearance: /
• Density: 0.94g/cm³
• Vapor Pressure: 0.0776mmHg at 25°C
• Refractive Index: 1.497
• CAS DataBase Reference: 2,6,6-Trimethylcyclohexa-1,3-dien-1-ylcarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6,6-Trimethylcyclohexa-1,3-dien-1-ylcarbonitrile(72152-84-2)
• EPA Substance Registry System: 2,6,6-Trimethylcyclohexa-1,3-dien-1-ylcarbonitrile(72152-84-2)

Safety Data

• Hazardous Substances Data: 72152-84-2(Hazardous Substances Data)

Usage

Description

2,6,6-Trimethylcyclohexa-1,3-dien-1-ylcarbonitrile is an organic compound characterized by its unique molecular structure, which features a cyclohexane ring with three methyl groups and a carbonitrile functional group. 2,6,6-Trimethylcyclohexa-1,3-dien-1-ylcarbonitrile has potential applications in various industries due to its specific chemical properties.

Uses

Used in Pharmaceutical Industry:
2,6,6-Trimethylcyclohexa-1,3-dien-1-ylcarbonitrile is used as a therapeutic agent for treating ocular diseases associated with increased all-trans retinal in ocular tissue. Its application is based on its ability to address the underlying cause of the disease by targeting and managing the levels of all-trans retinal, which is crucial for maintaining healthy ocular function.

InChI:InChI=1/C10H13N/c1-8-5-4-6-10(2,3)9(8)7-11/h4-5H,6H2,1-3H3

Upstream product

• 57524-14-8 2,2,6-trimethyl-1-cyclohexenylcarbonitrile 
• 145106-79-2 3-hydroxy-2,6,6-trimethylcyclohex-1-enecarbonitrile 
• 145106-80-5 2,6,6-Trimethyl-3-bromocyclohex-1-ene-1-carbonitrile 
• 108-24-7 acetic anhydride 
• 57524-13-7 2,6,6-trimethyl-2-cyclohexenecarbonitrile 
• 264279-20-1 2,3-epoxy-2,6,6-trimethyl-1-cyclohexanecarbonitrile 
• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 56830-39-8 2,4,4-Trimethylcyclohex-2-en-1-one-3-carbonitrile 
• 103324-66-9 1-hydroxy-2,2,6-trimethyl-cyclohexanecarbonitrile 
• 78887-20-4 (1S,5S) 4,4-Dimethyl-1-(1-methylethyl)-bicyclo<3.1.0>hexan-3-one 
• 145106-57-6 (1S,2S,5S) 1-(1-Methylethyl)-2,4,4-trimethylbicyclo<3.1.0>hexan-3-one 
• 145106-55-4 (1S,2R,5S) 1-(1-Methylethyl)-2,4,4-trimethylbicyclo<3.1.0>hexan-3-one 
• 73661-48-0 oxime 2,6,6-trimethylcyclohex-1-ene-1-carbaldehyde 
• 110-93-0 6-Methyl-hept-5-en-2-on 

Downstream Products

• 35044-69-0 2-Allyl-2,6,6-trimethyl-cyclohex-3-enecarbonitrile 
• 35044-70-3 4-Allyl-2,6,6-trimethyl-cyclohex-2-enecarbonitrile 
• 116-26-7 safranal 
• 42926-75-0 2,6,6-trimethyl-4-hydroxy-1-cyclohexene-1-carboxaldehyde 
• 23726-93-4 Damascenon 
• 78182-05-5 (E)-1-(2,6,6-Trimethylcyclohexa-1,3-dienyl)but-2-en-1-ol 
• 6890-91-1 (3RS,all-E)-hydroxyretinal 
• 7584-74-9 C₂₀H₂₈O₂ 

Relevant articles and documents

COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS

A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a primary amine compound of formula (I); and pharmaceutically acceptable salts thereof.

Synthetic scheme for the preparation of 13C-labeled 3,4-didehydro-retinal, 3-hydroxyretinal, and 4-hydroxyretinal up to uniform 13C-enrichment

A modular synthetic scheme has been developed for the synthesis of 13C-labeled naturally occurring visual pigment chromophores; 3,4-didehydroretinal, 3-hydroxyretinal, and 4-hydroxyretinal. These compounds can now be made with > 99% 13C enrichment at any position or combination of positions. We used the common C10+C5+C5 scheme for the synthesis of retinals, and by making variations in the C10 part we can now prepare the desired retinal derivatives with selective or uniform 13C enrichment. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.