723286-86-0Relevant articles and documents
QUINOLINE DERIVATIVES AS SMO INHIBITORS
-
Paragraph 0117; 0119, (2017/02/28)
Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing subsituted triazolopiperazines
Kim, Dooseop,Kowalchick, Jennifer E.,Brockunier, Linda L.,Parmee, Emma R.,Eiermann, George J.,Fisher, Michael H.,He, Huaibing,Leiting, Barbara,Lyons, Kathryn,Scapin, Giovanna,Patel, Sangita B.,Petrov, Aleksandr,Pryor, Kelly Ann D.,Roy, Ranabir Sinha,Wu, Joseph K.,Zhang, Xiaoping,Wyvratt, Matthew J.,Zhang, Bei B.,Zhu, Lan,Thornberry, Nancy A.,Weber, Ann E.
, p. 589 - 602 (2008/09/17)
A series of β-aminoamides bearing triazolopiperazines have been discovered as potent, selective, and orally active dipeptidyl peptidase IV (DPP-4) inhibitors by extensive structure-activity relationship (SAR) studies around the triazolopiperazine moiety.
