72358-71-5Relevant articles and documents
Selective Functionalization of Aminoheterocycles by a Pyrylium Salt
Moser, Daniel,Duan, Yaya,Wang, Feng,Ma, Yuanhong,O'Neill, Matthew J.,Cornella, Josep
, p. 11035 - 11039 (2018/07/31)
The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C?N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C?O, C?N, C?S, or C?SO2R bonds are disclosed herein. In contrast to C?N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional-group tolerance. In addition to small-molecule derivatization, Pyry-BF4 allows the introduction of functional groups in a late-stage fashion to furnish highly functionalized structures.
Chain transfer kinetics of acid/base switchable n -aryl- n -pyridyl dithiocarbamate RAFT agents in methyl acrylate, n -vinylcarbazole and vinyl acetate polymerization
Keddie, Daniel J.,Guerrero-Sanchez, Carlos,Moad, Graeme,Mulder, Roger J.,Rizzardo, Ezio,Thang, San H.
experimental part, p. 4205 - 4215 (2012/08/07)
The structures of the "Z" and "R" substituents of a RAFT agent (Z-C(S)S-R) determine a RAFT agent's ability to control radical polymerization. In this paper we report new acid/base switchable N-aryl-N-pyridyl dithiocarbamates (R = -CH2CN, Z = -N(Py)(Ar)) which vary in substituent at the 4-position of the aryl ring and the use of these to control molecular weight and dispersity. In their protonated form, the new RAFT agents are more effective in controlling polymerization of the more activated monomer, methyl acrylate (MA), whereas in their neutral form they provide more effective control of the polymerization of less activated monomers, N-vinyl carbazole (NVC) and vinyl acetate (VAc). For each polymerization, the apparent chain transfer coefficient (Ctrapp) shows a good correlation with Hammett parameters. Dithiocarbamates with more electron-withdrawing aryl ring substituents have the higher Ctr app. This demonstrates the influence of polar effects on C trapp and supports the hypothesis that the activity of these RAFT agents is determined by the availability of the lone pair of the dithiocarbamate nitrogen. Published 2012 by the American Chemical Society.
Bispyridinamines: A New Class of Topical Antimicrobial Agents as Inhibitors of Dental Plaque
Bailey, Denis M.,DeGrazia, C. George,Hoff, Stephanie J.,Schulenberg, Patsy L.,O'Connor, John R.,et al.
, p. 1457 - 1464 (2007/10/02)
A series of N,N'-polyalkylenebis has been prepared, and members have been evaluated as potential anti-dental plaque agents.From among the most active members of the series, one compound, N,N'-bis(1-octanamine) dihydrochloride, octenidine, was selected as a candidate for clinical study.
