72473-09-7

Basic information

• Product Name: coahuilensol, methyl ether
• Synonyms: coahuilensol, methyl ether
• CAS NO: 72473-09-7
• Molecular Weight: 148.205
• Mol File: 72473-09-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: coahuilensol, methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: coahuilensol, methyl ether(72473-09-7)
• EPA Substance Registry System: coahuilensol, methyl ether(72473-09-7)

Safety Data

• Hazardous Substances Data: 72473-09-7(Hazardous Substances Data)

Upstream product

• 18362-36-2 2-hydroxy-6-methylbenzaldehyde 
• 27200-84-6 methyl triphenylphosphonium bromide 
• 74-88-4 methyl iodide 
• 2944-49-2 2,3-dimethylanisole 
• 54884-55-8 2-methoxy-6-methyl-benzaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 526-75-0 2,3-Dimethylphenol 

Downstream Products

• 72473-08-6 7ξ-(3-hydroxy-propyl)-2c-(2-methoxy-6-methyl-phenyl)-(3ar)-hexahydro-pyrrolo[1,2-b]isoxazole; bromide 
• 72473-07-5 2c-(2-methoxy-6-methyl-phenyl)-(3ar)-hexahydro-pyrrolo[1,2-b]isoxazole 

Relevant articles and documents

The Key Role of the Nonchelating Conformation of the Benzylidene Ligand on the Formation and Initiation of Hoveyda-Grubbs Metathesis Catalysts

Experimental studies of Hoveyda-Grubbs metathesis catalysts reveal important consequences of substitution at the 6-position of the chelating benzylidene ligand. The structural modification varies conformational preferences of the ligand that affects its exchange due to the interaction of the coordinating site with the ruthenium center. As a consequence, when typical S-chelated systems are formed as kinetic trans-Cl2 products, for 6-substituted benzylidenes the preference is altered toward direct formation of thermodynamic cis-Cl2 isomers. Activity data and reactions with tricyclohexylphosphine (PCy3) support also a similar scenario for O-chelated complexes, which display fast trans-Cl2?cis-Cl2 equilibrium observed by NMR EXSY studies. The presented conformational model reveals that catalysts, which cannot adopt the optimal nonchelating conformation of benzylidene ligand, initiate through a high-energy associative mechanism.