72599-85-0

Basic information

• Product Name: C₆₆H₈₈Cl₃N₈O₁₃PSi₃
• Synonyms: C₆₆H₈₈Cl₃N₈O₁₃PSi₃
• CAS NO: 72599-85-0
• Molecular Weight: 1423.06
• Mol File: 72599-85-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₆H₈₈Cl₃N₈O₁₃PSi₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₆H₈₈Cl₃N₈O₁₃PSi₃(72599-85-0)
• EPA Substance Registry System: C₆₆H₈₈Cl₃N₈O₁₃PSi₃(72599-85-0)

Safety Data

• Hazardous Substances Data: 72599-85-0(Hazardous Substances Data)

Upstream product

• 69504-15-0 2',3'-O,O-bis(t-butyldimethylsilyl)adenosine 
• 60010-51-7 β,β,β-trichloroethyl phosphorodichloridite 
• 72409-30-4 N⁴-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-monomethoxytrityl)cytidine 

Downstream Products

• 2382-66-3 Cytidin-(3',5')-adenosin 
• 72624-28-3 C₄₆H₇₂Cl₃N₈O₁₂PSi₃ 

Relevant articles and documents

The chemical synthesis of oligoribonucleotides. IX. A comparison of protecting groups in the dichloridite procedure

A series of phosphorodichloridites has been prepared incorporating the most commonly used phosphate protecting groups in oligonucleotide synthesis.The groups incude trichloroethyl, tribromoethyl, cyanoethyl, benzyl, methyl, p-chlorophenyl, and nitrophenetyl.The trichloroethyl and the nitrophenethyl appear to be the most stable groups while the cyanoethyl and methyl offer specific advantages.The benzyl and p-chlorophenyl groups are subject to limitations on their utility.Condensations can be carried out in a range of solvents incuding THF, pyridine, and DMF and at temperatures from -78 deg C to 20 deg C with a slight drop in yield with increasing temperature, at least for dinucleotide condensations.