72656-82-7Relevant articles and documents
A flexible, efficient synthesis of (±)-carbocyclic phosphonic acid nucleoside derivatives
Wainwright, Phillip,Maddaford, Adrian,Bissell, Richard,Fisher, Ray,Leese, David,Lund, Andrew,Runcie, Karen,Dragovich, Peter S.,Gonzalez, Javier,Kung, Pei-Pei,Middleton, Donald S.,Pryde, David C.,Stephenson, Peter T.,Sutton, Scott C.
, p. 765 - 768 (2007/10/03)
An efficient and flexible synthesis of cyclopentane and hydroxylated cyclopentane phosphonic acid analogues is described. The key step involves the opening of an epoxide with either a nucleoside base or a selenyl anion to access the target molecules.
Highly efficient and enantioselective synthesis of carbocyclic nucleoside analogs using selective early transition metal catalysis
Martinez, Luis E.,Nugent, William A.,Jacobsen, Eric N.
, p. 7963 - 7966 (2007/10/03)
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Concise Racemic and Highly Enantioselective Approaches to Key Intermediates for the Syntheses of Carbocyclic Nucleosides and pseudo-Ribofuranoses: Formal Syntheses of Carbovir
Hodgson, David M.,Witherington, Jason,Moloney, Brian A.
, p. 3373 - 3378 (2007/10/02)
A regio- and stereo-specific synthesis of cis-(+/-)-3-acetoxy-5-(acetoxymethyl)cyclopentene 3 from cyclopent-3-enecarboxylic acid 4 via a bromolactonisation strategy is described.Pd-catalysed coupling of the cis-(+/-)-diacetate 3 with 2-amino-6-chloropurine or 2,6-diaminopurine leads to the formal syntheses of carbovir 1.A synthesis of the (1R)-cis-diacetate 15 (R = Ac) is described via a highly enantioselective rearrangement of cis-6-oxabicyclohexane-3-methanol 13 (also prepared from the acid 4) using the dilithium salt of (1S,2R)-norephedrine.
