852364-14-8

Basic information

• Product Name: Toluene-4-sulfonic acid (1S,3S,5R)-1-(6-oxa-bicyclo[3.1.0]hex-3-yl)methyl ester
• Synonyms: Toluene-4-sulfonic acid (1S,3S,5R)-1-(6-oxa-bicyclo[3.1.0]hex-3-yl)methyl ester
• CAS NO: 852364-14-8
• Molecular Weight: 268.334
• Mol File: 852364-14-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid (1S,3S,5R)-1-(6-oxa-bicyclo[3.1.0]hex-3-yl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid (1S,3S,5R)-1-(6-oxa-bicyclo[3.1.0]hex-3-yl)methyl ester(852364-14-8)
• EPA Substance Registry System: Toluene-4-sulfonic acid (1S,3S,5R)-1-(6-oxa-bicyclo[3.1.0]hex-3-yl)methyl ester(852364-14-8)

Safety Data

• Hazardous Substances Data: 852364-14-8(Hazardous Substances Data)

Upstream product

• 72656-82-7 anti-3-(Hydroxymethyl)-6-oxabicyclo<3.1.0>hexane 
• 98-59-9 p-toluenesulfonyl chloride 
• 35357-77-8 dimethyl bisallylmalonate 
• 58101-60-3 methyl cyclopent-3-ene-1-carboxylate 
• 25125-21-7 4-(hydroxymethyl)cyclopentene 
• 84646-68-4 Dimethyl 3-cyclopentene-1,1-dicarboxylate 
• 144534-62-3 (3'-cyclopentene)-1-methyl tert-butyldimethylsilylether 
• 144534-66-7 tert-butyldimethylsilyl (3,4-epoxycyclopentyl)methyl ether 
• 7686-77-3 3-cyclopentene-1-carboxylic acid 
• 86885-57-6 trans-3-carbomethoxy-6-oxabicyclo<3.1.0>hexane 

Relevant articles and documents

Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon

The synthesis of carbocyclic and phosphonocarbocyclic analogues of ribavirin, an anti-HCV inhibitor, are described. Those compounds were evaluated against HCV but also against other important viruses in order to determine their spectrum of antiviral activity. Compounds 6 and 13 displayed a moderate IC50 against HIV-1 of 43.8 and 37 μM, respectively.

Synthesis of carbocyclic phosphononucleosides

Syntheses of carbocyclic analogs of phosphononucleosides are described by two different methods (introduction of the heterocycle under Mitsunobu conditions or build-up of the base around a cyclopentylamine moiety).