7266-32-2

Basic information

• Product Name: 9H-Pyrrolo[2,3-b:5,4-c']dipyridine
• Synonyms: 9H-Pyrrolo[2,3-b:5,4-c']dipyridine
• CAS NO: 7266-32-2
• Molecular Formula: C10H7N3
• Molecular Weight: 169.18268
• Mol File: 7266-32-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 412.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.381±0.06 g/cm3(Predicted)
• PKA: 12.38±0.40(Predicted)
• CAS DataBase Reference: 9H-Pyrrolo[2,3-b:5,4-c']dipyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Pyrrolo[2,3-b:5,4-c']dipyridine(7266-32-2)
• EPA Substance Registry System: 9H-Pyrrolo[2,3-b:5,4-c']dipyridine(7266-32-2)

Safety Data

• Hazardous Substances Data: 7266-32-2(Hazardous Substances Data)

Upstream product

• 67-66-3 chloroform 
• 202344-41-0 1-(pyridin-4-ylmethyl)-1H-pyrazol-5-amine 
• 1069137-36-5 4-(3-nitropyridin-3-yl)pyridine 
• 13091-23-1 4-chloro-3-nitropyridine 
• 239137-39-4 3-amino-4-bromopyridine 
• 5029-67-4 2-iodopyridine 

Relevant articles and documents

TRICYCLIC CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Pyrolysis of 1-substituted pyrazoles and chloroform at 550°C: Formation of α-carboline from 1-benzylpyrazoles

Pyrolysis of 13CH3 labelled 1-methylpyrazole 8 with chloroform at 550°C in a continuous flow reactor yields unlabelled 2-chloropyrimidine 9 and 2-cyanopyrrole 10 labelled at the cyano group. However, pyrolysis of 1-benzylpyrazole 14 with chloroform under similar conditions gives 9,2-phenylpyrimidine 13 and, as the major product, α-carboline 15. Pyrolysis of several substituted 1-(arylmethyl)pyrazoles and the use of 13C and 15N labelled compounds provides direct evidence by which the positions of 7 atoms of 1-benzylpyrazole can be located in the α-carboline. These data support the mechanisms suggested for the formation of 9, 10, and 15.