72744-54-8

Basic information

• Product Name: 5-BROMO-1 3-BENZODIOXOLE-4-CARBOXALDEHY&
• Synonyms: 5-BROMO-1 3-BENZODIOXOLE-4-CARBOXALDEHY&;5-broMobenzo[d][1,3]dioxole-4-carbaldehyde;5-Bromo-1,3-benzodioxole-4-carboxaldehyde 96%;5-bromo-1,3-benzodioxole-4-carbaldehyde
• CAS NO: 72744-54-8
• Molecular Formula: C₈H₅BrO₃
• Molecular Weight: 229.0275
• Product Categories: Aldehydes;C8;Carbonyl Compounds
• Mol File: 72744-54-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 162-166 °C(lit.)
• Boiling Point: 309.28°C at 760 mmHg
• Flash Point: 140.848°C
• Appearance: /
• Density: 1.783g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 5-BROMO-1 3-BENZODIOXOLE-4-CARBOXALDEHY&(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1 3-BENZODIOXOLE-4-CARBOXALDEHY&(72744-54-8)
• EPA Substance Registry System: 5-BROMO-1 3-BENZODIOXOLE-4-CARBOXALDEHY&(72744-54-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 72744-54-8(Hazardous Substances Data)

Usage

General Description

5-Bromo-1,3-benzodioxole-4-carboxaldehyde is a chemical compound with the molecular formula C9H7BrO3. It is a colorless to pale yellow liquid with a sweet, floral odor. This chemical is used as an intermediate in the synthesis of various pharmaceutical compounds and as a building block in the production of fragrances and flavors. It is also utilized in the synthesis of organic compounds and has potential applications in the field of organic chemistry. However, it is important to handle and store this compound with care, as it can be irritating to the skin, eyes, and respiratory system, and it may pose environmental hazards if not properly managed.

InChI:InChI=1/C8H5BrO3/c9-6-1-2-7-8(5(6)3-10)12-4-11-7/h1-3H,4H2

Upstream product

• 83983-71-5 6-bromo-2,3-dihydroxybenzaldehyde 
• 74-95-3 1,1-dibromomethane 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 20035-41-0 6-bromo-2-hydroxy-3-methoxybenzaldehyde 
• 92252-86-3 1,1-diacetoxy-1-(2-acetoxy-3-methoxyphenyl)methane 
• 109548-06-3 6-Brom-2-acetoxy-3-methoxy-benzaldehyddiacetat 
• 492-88-6 3-ethoxysalicylaldehyde 
• 20035-45-4 6-bromo-3-ethoxy-2-hydroxybenzaldehyde 

Downstream Products

• 72744-56-0 5-bromobenzo[d][1,3]dioxole-4-carboxylic acid 
• 522-30-5 norsanguinarine 
• 1099616-40-6 6,7-dipropyl-N-p-tolyl-8H-indeno[5,4-d][1,3]dioxol-8-amine 
• 1217171-65-7 5-(2-formylphenyl)-1,3-benzodioxole-4-carbaldehyde 
• 1268368-30-4 C₁₉H₁₄O₆ 
• 33458-77-4 7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester 
• 1375467-89-2 C₂₇H₁₉NO₆ 
• 1375467-90-5 C₂₇H₂₁NO₆ 
• 1375467-84-7 C₂₇H₃₅NO₄Si 
• 1375467-85-8 C₂₉H₃₇NO₄Si 
• 1375467-86-9 C₂₀H₁₇NO₄ 
• 1375467-87-0 C₃₆H₄₁NO₆Si 

Relevant articles and documents

Ortho-directed lithiation of 3, 4-(alkylenedioxy)halobenzenes with LDA and LiTMP. The first ortho lithiation of 1 an lodobenzene

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Re-engineering and synthesis of cytotoxic 2,3:7,8-di(alkylenedioxy)-extended analogs of quaternary sanguinarine chloride

A method was developed to synthesize 2,3:7,8-di(alkylenedioxy)-extended analogs of quaternary sanguinarine chloride. 1-Bromo-2-bromomethyl-3,4-alkylenedioxy benzenes and 6,7-alkylenedioxynaphthalen-1-amines were synthesized first. Reactions to construct the target compounds with these two series of synthons involved alterations on a published method for synthesizing 2,3,7,8-tetraoxygenated derivatives of benzo[c]phenanthridinium, substituting benzyl bromides for benzoic aldehydes, prolonging the radical annulation time, and conducting N-methylation with formic acid and NaBH4. All the target compounds showed the same or better in vitro growth inhibitory activities against cancer cell lines compared with the positive compound. The structure activity relationship relevant to cytotoxicity and lipophilicity of the target compounds was produced.

Total synthesis of (+)-linoxepin by utilizing the catellani reaction

Molecular intelligence: The structurally novel lignan (+)-linoxepin is synthesized in an eight-step sequence. The enantioselective synthesis features the palladium-catalyzed Catellani reaction as the key step. In this highly convergent multicomponent reaction, two new carbon-carbon bonds are formed, one of which results from a C-H bond functionalization. Copyright