727993-33-1

Basic information

• Product Name: 6-Methoxy-2-trifluoromethyl-3-nitropyridine
• Synonyms: 6-Methoxy-2-trifluoromethyl-3-nitropyridine;6-METHOXY-3-NITRO-2-TRIFLUOROMETHYL-PYRIDINE
• CAS NO: 727993-33-1
• Molecular Formula: C₇H₅F₃N₂O₃
• Molecular Weight: 222.12
• Product Categories: Pyridine series;Pyridines
• Mol File: 727993-33-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 256.4°C at 760 mmHg
• Flash Point: 108.8°C
• Appearance: /
• Density: 1.461g/cm³
• Vapor Pressure: 0.0248mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Methoxy-2-trifluoromethyl-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methoxy-2-trifluoromethyl-3-nitropyridine(727993-33-1)
• EPA Substance Registry System: 6-Methoxy-2-trifluoromethyl-3-nitropyridine(727993-33-1)

Safety Data

• Hazardous Substances Data: 727993-33-1(Hazardous Substances Data)

Usage

Uses

6-Methoxy-3-nitro-2-(trifluoromethyl)pyridine is used in the synthasis of pyrazinones as corticotropin-releasing factor -1 (CFR1) receptor antagonists.

InChI:InChI=1/C7H5F3N2O3/c1-15-5-3-2-4(12(13)14)6(11-5)7(8,9)10/h2-3H,1H3

Upstream product

• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 
• 1514-87-0 metyhyl chlorodifluoroacetate 
• 75-61-6 dibromodifluoromethane 

Downstream Products

• 727993-34-2 6-methoxy-2-(trifluoromethyl)pyridin-3-amine 
• 503184-34-7 3-iodo-6-methoxy-2-(trifluoromethyl)pyridine 
• 503184-37-0 2'-benzyloxy-6-methoxy-3'-nitro-2-trifluoromethyl-[3,4']bipyridinyl 

Relevant articles and documents

Therapeutically Active Thiazolo-Pyrimidine Derivatives

A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

Heterocyclic cyclopropyl-substituted FXR binding compounds

The present invention relates to compounds defined by formula (I): or an enantiomer, diastereomer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently from each other selected from hydro

HETEROARYL- SUBSTITUTED PYRROLO` 2, 3- B! PYRIDINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS

The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).