72850-76-1

Basic information

• Product Name: 2-Amino-4-isopropyl-thiazole-5- carboxylic acid ethyl ester
• Synonyms: 2-Amino-4-isopropyl-thiazole-5- carboxylic acid ethyl ester;4-(2-aMino-thiazol-5-yl)-benzoic acid Methyl ester
• CAS NO: 72850-76-1
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.28466
• Mol File: 72850-76-1.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-Amino-4-isopropyl-thiazole-5- carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-isopropyl-thiazole-5- carboxylic acid ethyl ester(72850-76-1)
• EPA Substance Registry System: 2-Amino-4-isopropyl-thiazole-5- carboxylic acid ethyl ester(72850-76-1)

Safety Data

• Hazardous Substances Data: 72850-76-1(Hazardous Substances Data)

Usage

General Description

2-Amino-4-isopropyl-thiazole-5-carboxylic acid ethyl ester is a chemical compound with the molecular formula C10H16N2O2S. It is a derivative of thiazole and contains an amino group, isopropyl group, and carboxylic acid ethyl ester functional group. 2-Amino-4-isopropyl-thiazole-5- carboxylic acid ethyl ester is used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active molecules. It has potential applications in the development of new drugs for the treatment of various diseases. Additionally, it may also have industrial applications as a chemical intermediate in the production of other compounds.

Upstream product

• 35391-60-7 ethyl 2-chloro-4-methyl-3-oxopentanoate 
• 17356-08-0 thiourea 
• 81569-67-7 2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 78968-28-2 2-chloro-4-methyl-valeric acid ethyl ester 

Downstream Products

• 81569-57-5 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester 
• 81569-58-6 2-bromo-4-isopropyl-thiazole-5-carboxylic acid ethyl ester 
• 72850-75-0 Ethyl 2-chloro-4-i-propyl-5-thiazolecarboxylate 
• 81569-42-8 4-isopropylthiazole-5-carboxylic acid 
• 1251529-47-1 C₂₇H₃₅ClN₄O₄S 
• 1610853-10-5 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide 
• 72632-66-7 4-(propan-2-yl)-1,3-thiazol-5-amine 

Relevant articles and documents

Synthetic method of drug intermediate sulfur-containing nitrogen heterocyclic amine compound (by machine translation)

To the invention, 4 -N-BOC -3 - isopropylthiazole is obtained by reaction of 2 - methyl -4 - oxo-pentanoic acid ethyl ester, dichloromethane and sulfonyl chloride as a raw material, and then -3 - N-BOC - 2 - isopropylthiazole and HCl are added in the presence of ethanol as a solvent to obtain -4 - N-BOC-n-isopropythiazol -5 - methyl 4 -isoprop -5 -aminothiazole in the presence of triethylamine, and a NaOH solution is added as a solvent and then subjected to extraction washing to obtain 4 -yl -5 -aminothiazolethyl acetate in the presence of trifluoroethanol as a solvent and ethanol as a solvent to obtain ethyl acetate 4 - 5-propyl thiazole -5 - formic acid ethyl ester with ethanol as a 4 - solvent and an aqueous solution of N-BOC-5 n-isopropylthiazole 4 - and the like 4 -5 . The method has the advantages of clear steps, less waste, high yield, raw material saving and easy operation. (by machine translation)

SUBSTITUTED AMINO-ACRYLCARBOXAMIDES AS KCNQ2/3 MODULATORS

The invention relates to amino-arylcarboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Xanthan sulfuric acid: An efficient bio-supported and recyclable solid acid catalyst for the synthesis of 2-aminothiazole-5-carboxylates and 2-aminoselenazole-5-carboxylates

An efficient method has been developed for the synthesis of 2-amino thiazole and selenazole-5-carboxylates from β-ketoesters, thiourea or seleno urea and N-bromo succinamide by using Xanthan sulfuric acid as a solid acid catalyst. The reaction work-up is