730977-57-8

Basic information

• Product Name: ethyl 2-hydroxy-4-iodobenzoate
• Synonyms: ethyl 2-hydroxy-4-iodobenzoate
• CAS NO: 730977-57-8
• Molecular Weight: 292.073
• Mol File: 730977-57-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2-hydroxy-4-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-hydroxy-4-iodobenzoate(730977-57-8)
• EPA Substance Registry System: ethyl 2-hydroxy-4-iodobenzoate(730977-57-8)

Safety Data

• Hazardous Substances Data: 730977-57-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 16870-28-3 4-iodosalicylic acid 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 6059-17-2 ethyl 4-amino-2-hydroxybenzoate 

Downstream Products

• 16870-28-3 4-iodosalicylic acid 

Relevant articles and documents

Bi-aryl analogues of salicylic acids: Design, synthesis and sar study to ameliorate endoplasmic reticulum stress

Introduction: Endoplasmic reticulum (ER) stress condition is characterized as the accu-mulation of misfolded or unfolded proteins in lumen of ER. This condition has been implicated in various diseases and pathologies including β-cell apoptosis, Alzheimer’s disease and atherosclerosis. We have reported that hydroxynaphthoic acids (HNA), naphtha-lene analogues of salicylic acid (SA), reduced ER stress. In this study, we explored structural modification to bi-aryl analogues of SA. Methods: Palladium-catalyzed cross-coupling was applied to synthesize bi-aryl analogues of SA. Anti-ER stress activity was monitored by using our cell-based assay system where ER stress is induced by tunicamycin. To monitor ER stress markers, ER stress was induced physiologically relevant palmitate system. Results: Many analogues decreased ER stress signal induced by tunicamycin. Compounds creating dihedral angle between Ar group and SA moiety generally increased the activity but gave some cytotoxicity to indicate the crucial role of flat conformation of aromatic region. The best compound (16e) showed up to almost 6-fold and 90-fold better activity than 3-HNA and tauro-ursodeoxycholic acid, positive controls, respectively. ER stress markers such as p-PERK and p-JNK were accordingly decreased in Western blotting upon treatment of 16e under palmitate-induced condition. Conclusion: Anti-ER stress activity and toxicity profile of bi-aryl analogues of SA could provide a novel platform for potential therapy for protein misfolding diseases.

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group

An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.