732-34-3

Basic information

• Product Name: Methanone, [2-amino-5-(trifluoromethyl)phenyl]phenyl-
• CAS NO: 732-34-3
• Molecular Formula: C14H10F3NO
• Molecular Weight: 265.235
• Mol File: 732-34-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, [2-amino-5-(trifluoromethyl)phenyl]phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [2-amino-5-(trifluoromethyl)phenyl]phenyl-(732-34-3)
• EPA Substance Registry System: Methanone, [2-amino-5-(trifluoromethyl)phenyl]phenyl-(732-34-3)

Safety Data

• Hazardous Substances Data: 732-34-3(Hazardous Substances Data)

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 141940-37-6 tert-butyl (4-(trifluoromethyl)phenyl)carbamate 
• 2358-09-0 2-Amino-5-trifluormethylbenzophenonimin 
• 789-96-8 (2-chloro-5-(trifluoromethyl)phenyl)(phenyl)methanone 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 
• 328-87-0 2-chloro-5-(trifluoromethyl)benzonitrile 

Downstream Products

• 5219-89-6 3-Amino-4-phenyl-6-trifluoromethyl-1H-quinolin-2-one 
• 128831-57-2 2-(2-nitrovinyl amino)-5-trifluoromethylbenzophenone 
• 1433904-04-1 4-phenyl-3-(1H-tetrazol-5-yl)-6-trifluoromethyl-1H-quinolin-2-one 
• 1433904-05-2 2-chloro-4-phenyl-3-(1H-tetrazol-5-yl)-6-trifluoromethyl-quinoline 
• 1433902-52-3 4-phenyl-2-(piperidin-1-yl)-3-(1H-tetrazol-5-yl)-6-(trifluoromethyl)quinoline 
• 69559-51-9 2'-benzoyl-2,2,2-trichloro-4'-trifluoromethylacetanilide 
• 973-24-0 2-aminoacetamido-5-(trifluoromethyl)benzophenone 
• 21237-67-2 N-(2-Benzoyl-4-trifluoromethyl-phenyl)-2-chloro-acetamide 
• 851-74-1 2-Bromacetamido-5-trifluormethyl-benzophenon 
• 18509-89-2 5-Trifluormethyl-2--benzophenon 

Relevant articles and documents

QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS

Disclosed herein are certain quinolinone derivatives of Formula (A) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.