73219-44-0Relevant articles and documents
5-phenylpyrrolo-1,4-benzoxazine and 5-phenylpyrrolo-1,4-benzothiazine compounds, process and intermediates for their production and pharmaceutical compositions containing them
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, (2008/06/13)
Pharmacologically active compounds of formula I STR1 which can be substituted in the phenyl rings and in which R1 denotes hydrogen or lower alkyl, R2 denotes hydrogen or lower alkyl, Y denotes oxygen or sulfur n represents an integer from 1 to 3 Z represents a bond, a CO group or a CH= group, Q denotes nitrogen or the CH group and R7, if Q denotes nitrogen, represents an optionally substituted pyridyl or phenyl radical or, if Q denotes the CH group, represents the N-methyl-N-(4-oxo-3H-pyrimidin-2-yl)amino group, and their acid addition salts and processes and intermediates for their preparation.
A Convenient and One-Pot Synthesis of Methyl &α-(3,4-Dihydro-3-oxo-2H-1,4-benzoxazin-2-yl)acetates
Shridhar, S. R.,Ram, Bhagat,Rao, K. Srinivasa,Jain, M. L.
, p. 992 - 994 (2007/10/02)
A convenient and one-step method for the preparation of methyl α-(6-substituted 3,4-dihydro-3-oxo-2H-1,4-benzoxazin-2-yl)acetates (1a, and 8-14) is described.The reaction of appropriately substituted 2-aminophenols with maleic anhydride in the presence of Et3N gives the corresponding benzoxazinylacetates (1a and 8-10) while with methylmaleic anhydride, an initial nucleophilic attack at the more hindered carbonyl group takes place leading to the formation of the corresponding 2-methylbenzoxazinylacetates (11-14) in excellent yields.The antiinflammatory activity of these acetates (1a and 8-14) is also described.