73584-06-2

Basic information

• Product Name: Phosphonic acid, [chloro(4-fluorophenyl)methyl]-, diethyl ester
• CAS NO: 73584-06-2
• Molecular Formula: C11H15ClFO3P
• Molecular Weight: 280.663
• Mol File: 73584-06-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [chloro(4-fluorophenyl)methyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [chloro(4-fluorophenyl)methyl]-, diethyl ester(73584-06-2)
• EPA Substance Registry System: Phosphonic acid, [chloro(4-fluorophenyl)methyl]-, diethyl ester(73584-06-2)

Safety Data

• Hazardous Substances Data: 73584-06-2(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 21386-00-5 diethyl (4-fluorophenyl)hydroxymethylphosphonate 
• 456-19-9 4-fluorobenzal chloride 
• 122-52-1 triethyl phosphite 
• 209627-01-0 [Chloro-(4-fluoro-phenyl)-trimethylsilanyl-methyl]-phosphonic acid diethyl ester 
• 63909-58-0 diethyl (4-fluorobenzyl)phosphonate 

Downstream Products

• 64583-20-6 4-((4-fluorophenyl)ethynyl)benzonitrile 
• 1181811-88-0 diethyl α,α-chlorofluoro-4-fluorobenzylphosphonate 
• 64583-19-3 1-bromo-4-((4-fluorophenyl)ethynyl)benzene 
• 64583-16-0 1-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzene 
• 405-29-8 (4-fluorophenyl)phenylacetylene 
• 64583-21-7 1-fluoro-4-(2-(4-nitrophenyl)ethynyl)benzene 
• 64583-18-2 1-(para-chlorophenyl)-2-(para-fluorophenyl)acetylene 
• 5216-31-9 1,2-bis(4-fluorophenyl)acetylene 
• 64583-17-1 1-(4-fluorophenyl)-2-(4-methylphenyl)acetylene 

Relevant articles and documents

Synthesis of new aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives

Simple and versatile synthetic procedures towards new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids via reactions of either aromatic aldehydes or their derivatives with phosphites were elaborated.

The first synthesis of diethyl α,α- chlorofluorobenzylphosphonates

Starting from a-hydroxyphosphonates, a wide variety of diethyl α,α-chlorofluorobenzylphosphonates have been obtained in pure form in a two-step procedure. The first step was chlorination of a- hydroxyphosphonates with Ph3P and CCl4,

Controlled monohalogenation of phosphonates: A new route to pure α- monohalogenated diethyl benzylphosphonates

Starting from diethyl benzylphosphonates, a wide variety of diethyl α- monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSCI followed by halogenation with an electrophilic halogenating reagent.