73747-40-7Relevant articles and documents
A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H
Ivkovic, Jakov,Lembacher-Fadum, Christian,Breinbauer, Rolf
, p. 10456 - 10460 (2015/11/10)
N-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.
IMPROVED AMINOHYDROXYLATION OF ALKENES
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Page/Page column 51, (2012/01/06)
The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.
Facile Reduction of Intermediates from Carboxylic Acids and 6-Nitro-1-(2-nitrophenylsulfonyloxy)benzotriazole with Sodium Borohydride to Alcohols
Okawara, Tadashi,Ikeda, Norihiro,Yamasaki, Tetsuo,Furukawa, Mitsuru
, p. 3628 - 3631 (2007/10/02)
Reduction of activated intermediates derived from 6-nitro-1-(2-nitrophenylsulfonyloxy)-benzotriazole and carboxylic acids with sodium borohydride readily afforded the corresponding alcohols in 71-93percent yields.Keywords: 6-nitro-1-(2-nitrophenylsulfonyloxy)benzotriazole; 1-acyloxy-6-nitrobenzotriazole; 3-acyl-6-nitrobenzotriazole 1-oxide; sodium borohydride reduction; alcohol synthesis