740809-75-0Relevant articles and documents
Methods and compositions for treating cancer
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Page/Page column 14, (2010/02/15)
The invention provides compounds and methods for treating cancer. Exemplary compounds are multi-functional compounds with two different moieties connected by a linker. Compounds of the invention can activate one or more pathways that result in the inhibit
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells
Mitra, Kaushik,Marquis, John C.,Hillier, Shawn M.,Rye, Peter T.,Zayas, Beatriz,Lee, Annie S.,Essigmann, John M.,Croy, Robert G.
, p. 1862 - 1863 (2007/10/03)
We describe a novel strategy to increase the selective toxicity of genotoxic compounds. The strategy involves the synthesis of bifunctional molecules capable of forming DNA adducts that have high affinity for specific proteins in target cells. It is propo