740842-71-1Relevant articles and documents
Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor
Naganathan, Sriram,Andersen, Denise L.,Andersen, Neil G.,Lau, Stephen,Lohse, Anders,Sorensen, Mads Detlef
, p. 721 - 734 (2015)
The benzoxazepine core is present in several kinase inhibitors, including the mTOR inhibitor 1. The process development for a scalable synthesis of 7-bromobenzoxazepine and the telescoped synthesis of 1 are reported. Compound 1 consists of three chemicall