1251156-08-7

Basic information

• Product Name: XL-388
• Synonyms: Methanone, [7-(6-amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-;[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone XL388;XL388, >=98%;(7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methy;XL 388;XL388;XL-388;[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
• CAS NO: 1251156-08-7
• Molecular Formula: C₂₃H₂₂FN₃O₄S
• Molecular Weight: 455.5018832
• Product Categories: Inhibitors;Akt;mTOR;PI3K;PI3K/Akt/mTOR
• Mol File: 1251156-08-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 738.6±60.0 °C(Predicted)
• Appearance: /
• Density: 1.354±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 6.22±0.13(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: XL-388(CAS DataBase Reference)
• NIST Chemistry Reference: XL-388(1251156-08-7)
• EPA Substance Registry System: XL-388(1251156-08-7)

Safety Data

• Hazardous Substances Data: 1251156-08-7(Hazardous Substances Data)

Usage

Uses

XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.

Upstream product

• 1251164-88-1 3-fluoro-2-methyl-4-(methylsulfonyl)benzoyl chloride 
• 1251165-18-0 5-(2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)pyridin-2-amine 
• 1251162-64-7 tert-butyl 7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo-[f ][1,4]oxazepine-4(5H)-carboxylate 
• 118939-18-7 3-fluoro-2-methyl-4-(methylsulfonyl)benzoic acid 
• 740842-73-3 1,1-dimethylethyl 7-bromo-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate 
• 1251164-95-0 tert-butyl 7-dihydroxyboryl-2,3-dihydro-5H-benzo[f ]-[1,4]-oxazepine-4(5H)-carboxylate 
• 1761-61-1 5-bromosalicyclaldehyde 
• 21974-51-6 4-bromo-2-[(2-hydroxyethyl)-iminomethyl]phenol 
• 1181407-01-1 C₉H₁₂BrNO₂ 
• 1217862-54-8 tert-butyl N-(5-bromo-2-hydroxybenzyl)-N-(2-hydroxyethyl)carbamate 
• 847502-81-2 1-bromo-3,4-difluoro-2-methyl-benzene 
• 3828-49-7 1,2-difluoro-3-methyl-benzene 
• 157652-31-8 3,4-difluoro-2-methyl benzoic acid 
• 118287-06-2 3-fluoro-2-methyl-4-(thiomethyl)benzoic acid 

Relevant articles and documents

Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor

The benzoxazepine core is present in several kinase inhibitors, including the mTOR inhibitor 1. The process development for a scalable synthesis of 7-bromobenzoxazepine and the telescoped synthesis of 1 are reported. Compound 1 consists of three chemicall

BENZOXAZEPIN-4- (5H) -YL DERIVATIVES AND THEIR USE TO TREAT CANCER

The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.