847502-81-2

Basic information

• Product Name: 6-BROMO-2,3-DIFLUOROTOLUENE
• Synonyms: 6-BROMO-2,3-DIFLUOROTOLUENE
• CAS NO: 847502-81-2
• Molecular Formula: C₇H₅BrF₂
• Molecular Weight: 207.02
• Product Categories: Aromatic Halides (substituted);Aryl;Organohalides
• Mol File: 847502-81-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 182.7°C at 760 mmHg
• Flash Point: 64.3°C
• Appearance: /
• Density: 1.588g/cm³
• Vapor Pressure: 1.09mmHg at 25°C
• Refractive Index: 1.5105
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-BROMO-2,3-DIFLUOROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2,3-DIFLUOROTOLUENE(847502-81-2)
• EPA Substance Registry System: 6-BROMO-2,3-DIFLUOROTOLUENE(847502-81-2)

Safety Data

• Hazardous Substances Data: 847502-81-2(Hazardous Substances Data)

Usage

Uses

3,4-Difluoro-2-methylbromobenzene

InChI:InChI=1/C7H5BrF2/c1-4-5(8)2-3-6(9)7(4)10/h2-3H,1H3

Upstream product

• 3828-49-7 1,2-difluoro-3-methyl-benzene 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 847502-83-4 3,4-difluoro-2-methylbenzonitrile 
• 1188412-52-3 (2R)-1-(3,4-difluoro-2-methylphenyl)propan-2-ol 
• 157652-31-8 3,4-difluoro-2-methyl benzoic acid 
• 1251150-14-7 C₂₅H₂₂FN₃O₄S 
• 1251156-08-7 [7-(6-aminopyridin-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)-phenyl]methanone 
• 118939-18-7 3-fluoro-2-methyl-4-(methylsulfonyl)benzoic acid 
• 118287-06-2 3-fluoro-2-methyl-4-(thiomethyl)benzoic acid 
• 1251164-88-1 3-fluoro-2-methyl-4-(methylsulfonyl)benzoyl chloride 
• 1188412-57-8 (1S)-2-(3,4-difluoro-2-methylphenyl)-1-methylethyl azide 
• 1188413-04-8 C₁₁H₁₄F₂O₃S 
• 1985607-83-7 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol 
• 2136287-66-4 7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one 
• 2136287-65-3 3,4-difluoro-2-((phenylthio)methyl)benzoic acid 
• 160775-14-4 3,4-difluoro-2-methylbenzoic acid methyl ester 

Relevant articles and documents

Method for preparing baloxavir intermediate and intermediate obtained by method

The invention belongs to the technical field of chemical synthesis, and provides a method for preparing a balosavir intermediate. The method comprises the following steps: (1) methylating 3,4-difluorobromobenzene to obtain a compound A-1; (2) reacting the compound A-1 with a Grignard reagent, then introducing carbon dioxide gas for reaction, and adding acid for acidification to obtain a compound A-2; (3) brominating the compound A-2 to obtain a compound A-3; (4) adding diphenyl disulfide and a reducing agent 1 into THF, dropwise adding methanol, dropwise adding the compound A-3, and reacting to obtain a compound A-4; (5) carrying out ring closing reaction on the compound A-4 in polyphosphoric acid to obtain a compound A-5; and (6) reducing the compound A-5 into alcohol by adopting a reducing agent 2 to obtain a compound A-6. According to the method, highly toxic and foul thiophenol is prevented from being used while expensive reagents are prevented from being used, so that the processcost is reduced. The invention also provides an intermediate compound prepared by the method.

CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Preparation method of 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol

The invention relates to a preparation method of 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol. According to the method, specifically, 2,3-difluorotoluene is adopted as a raw material, and 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol is e