847502-83-4Relevant articles and documents
FLUORINE-CONTAINING THALIDOMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING THE SAME
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Paragraph 0077-0079, (2021/09/29)
PROBLEM TO BE SOLVED: To provide a novel thalidomide three-agents derivative that has a similar structure to those of three thalidomide agents (thalidomide, lenalidomide, pomalidomide) but has oxidative metabolism resistant activity and can avoid teratogenicity. SOLUTION: A fluorinated thalidomide three-agents derivative is represented by the formula (1) (R1, R2, R3 are the same or different to represent H or F, where at least one of R1, R2, R3 is F; R4 is H or an optionally substituted hydroxy, alkoxy, acyl, acyloxy or alkyl group; X is H, F or an optionally substituted amino group; Y is -C(=O)- or -CH2-). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
Difluoroalkylaromatics
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Page/Page column 4, (2010/02/11)
The present invention relates to 3,4-difluoro-2-alkylaromatics and 2,4-difluoro-3-alkylaromatics, to a process for their preparation and to their use for preparing active ingredients.