118287-06-2

Basic information

• Product Name: 3-fluoro-2-methyl-4-(thiomethyl)benzoic acid
• Synonyms: 3-fluoro-2-methyl-4-(thiomethyl)benzoic acid
• CAS NO: 118287-06-2
• Molecular Weight: 200.234
• Mol File: 118287-06-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-fluoro-2-methyl-4-(thiomethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-2-methyl-4-(thiomethyl)benzoic acid(118287-06-2)
• EPA Substance Registry System: 3-fluoro-2-methyl-4-(thiomethyl)benzoic acid(118287-06-2)

Safety Data

• Hazardous Substances Data: 118287-06-2(Hazardous Substances Data)

Upstream product

• 157652-31-8 3,4-difluoro-2-methyl benzoic acid 
• 5188-07-8 sodium thiomethoxide 
• 3828-49-7 1,2-difluoro-3-methyl-benzene 
• 847502-81-2 1-bromo-3,4-difluoro-2-methyl-benzene 

Downstream Products

• 1251150-14-7 C₂₅H₂₂FN₃O₄S 
• 1251156-08-7 [7-(6-aminopyridin-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)-phenyl]methanone 
• 118939-18-7 3-fluoro-2-methyl-4-(methylsulfonyl)benzoic acid 

Relevant articles and documents

Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor

The benzoxazepine core is present in several kinase inhibitors, including the mTOR inhibitor 1. The process development for a scalable synthesis of 7-bromobenzoxazepine and the telescoped synthesis of 1 are reported. Compound 1 consists of three chemicall