744197-16-8

Basic information

• Product Name: 4-{2-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-thiazol-4-yl}-3-p-tolyl-butyric acid ethyl ester
• CAS NO: 744197-16-8
• Molecular Weight: 463.644
• Mol File: 744197-16-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{2-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-thiazol-4-yl}-3-p-tolyl-butyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{2-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-thiazol-4-yl}-3-p-tolyl-butyric acid ethyl ester(744197-16-8)
• EPA Substance Registry System: 4-{2-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-thiazol-4-yl}-3-p-tolyl-butyric acid ethyl ester(744197-16-8)

Safety Data

• Hazardous Substances Data: 744197-16-8(Hazardous Substances Data)

Upstream product

• 351-54-2 3-fluoro-p-anisaldehyde 
• 10412-98-3 5-oxohexanenitrile 
• 7521-41-7 2-Aminonicotinaldehyde 
• 227938-80-9 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanenitrile 
• 724771-61-3 4-(3-fluoro-4-methoxy-phenyl)-dihydro-pyran-2,6-dione 
• 227938-79-6 4-[1,8]naphthyridin-2-yl-butyronitrile 
• 722549-38-4 ethyl 6-chloro-3-(4-methylphenyl)-5-oxohexanoate 
• 722549-49-7 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanethioamide 

Relevant articles and documents

Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin αvβ3 and show selectivity relative to the other integrins, such as αIIbβ 3 and αvβ6. These analogs were demonstrated to have high bioavailability relative to other relative heterocyclic analogs.