74420-43-2

Basic information

• Product Name: 3-Methyl-5-bromoimidazo<1,2-a>pyridine hydrobromide
• CAS NO: 74420-43-2
• Molecular Weight: 291.973
• Mol File: 74420-43-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Methyl-5-bromoimidazo<1,2-a>pyridine hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-5-bromoimidazo<1,2-a>pyridine hydrobromide(74420-43-2)
• EPA Substance Registry System: 3-Methyl-5-bromoimidazo<1,2-a>pyridine hydrobromide(74420-43-2)

Safety Data

• Hazardous Substances Data: 74420-43-2(Hazardous Substances Data)

Upstream product

• 19798-81-3 2-Amino-6-bromopyridine 
• 3400-55-3 2-bromopropionaldehyde diethyl acetal 

Relevant articles and documents

Reaction of 3-Substituted Imidazopyridines with Br+ and the Alleged 5-Bromo-Substituted Product

The reaction of 3-methylimidazopyridine with NBS was reinvestigated and is shown to give products formed by apparent nucleophilic substitution at the 2-position.NBS in CHCl3 gave compounds 4 and 6, while NBS in CCl4 or Br2 in CHCl3 gave exclusively 4.Mechanisms and differences in product formation are discussed; evidence that the previously reported NBS product was in fact 3-bromo-5-methylimidazopyridine, rather than the alleged 5-bromo-3-methyl derivative 3, is presented.Compound 3 was prepared by diazotization of 5-amino-3-methylimidazopyridine in the presence of HBr and by condensation of 2-bromopropanal (or its acetal) with 2-amino-6-bromopyridine (12).This latter reaction of the weakly basic aminopyridine 12 is shown to follow the normal pattern in which the amino nitrogen condenses with the carbonyl carbon.Structures are established by infrared, mass, and 1H-NMR spectral analyses, mechanistic considerations, and diagnostic reactions.Experimental and computer-generated 1H-NMR spectra of compounds 3 and 13 are reproduced.