19798-81-3

Basic information

• Product Name: 2-Amino-6-bromopyridine
• Synonyms: 6-Bromopyridine-2-amine;2-PyridinaMine,6-broMo-;2-AMino-6-broMopyridine, 98% 5GR;6-BROMO-PYRIDIN-2-YLAMINE;6-BROMO-2-PYRIDINAMINE;6-BROMO-2-AMINOPYRIDINE;2A6BP;2-AMINO-6-BROMOPYRIDINE
• CAS NO: 19798-81-3
• Molecular Formula: C₅H₅BrN₂
• Molecular Weight: 173.01
• EINECS: -0
• Product Categories: Amines;blocks;Bromides;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Pyridine series;Pyridines derivates;Bromopyridines;Halopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 19798-81-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 88-91 °C(lit.)
• Boiling Point: 272.954 °C at 760 mmHg
• Flash Point: 118.879 °C
• Appearance: Slightly yellow to light brown/Powder
• Density: 1.71 g/cm³
• Vapor Pressure: 0.0059mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Very Slightly)
• PKA: 2.73±0.24(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Amino-6-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-bromopyridine(19798-81-3)
• EPA Substance Registry System: 2-Amino-6-bromopyridine(19798-81-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 19798-81-3(Hazardous Substances Data)

Usage

Description

2-Amino-6-bromopyridine is a disubstituted pyridine derivative synthesized from epichlorohydrin. It is characterized by its slightly yellow to light brown powder appearance and is known for its versatile applications in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
2-Amino-6-bromopyridine is used as a building block for the preparation of nitrogen-containing bicyclic and polycyclic compounds, which are essential in the development of various pharmaceutical products.
Used in Organic Chemistry:
2-Amino-6-bromopyridine is employed in an efficient one-pot synthesis of 7-azaindoles, which are important intermediates in the synthesis of various organic compounds.
Used in Antiviral Applications:
2-Amino-6-bromopyridine is used as a key component in the synthesis of anti-HIV agents, contributing to the development of medications that combat the human immunodeficiency virus (HIV).

InChI:InChI=1/C5H5BrN2/c6-4-2-1-3-5(7)8-4/h1-3H,(H2,7,8)/p+1

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 408352-48-7 2-amino-4,6-dibromopyridine 
• 25218-99-9 N-(6-bromo-pyridin-2-yl)acetamide 
• 344331-90-4 tert-butyl 6-bromopyridin-2-ylcarbamate 
• 111753-05-0 5-bromo-3-nitroimidazo<1,2-a>pyridine 
• 69214-09-1 5-bromoimidazo<1,2-a>pyridine 
• 21190-87-4 6-bromo-pyridine-2-carboxylic acid 
• 1075-62-3 N-(6-aminopyridin-2-yl)acetamide 
• 110-86-1 pyridine 
• 2408-70-0 2,4,6-tribromopyridine 
• 98-92-0 nicotinamide 
• 144100-07-2 2-bromo-6-fluoropyridine 

Downstream Products

• 4945-46-4 3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-ylamine 
• 27992-32-1 6-bromo-2-hydroxypyridine 
• 17920-35-3 2-amino-6-methoxypyridine 
• 768-42-3 6-ethoxypyridin-2-amine 
• 89284-11-7 5,6-dibromopyridin-2-ylamine 
• 63875-38-7 3,5,6-tribromopyridin-2-amine 
• 4926-54-9 3-Methyl-5-bromoimidazo<1,2-a>pyridine 
• 74420-51-2 2-Methyl-5-bromoimidazo<1,2-a>pyridine 
• 74420-43-2 3-Methyl-5-bromoimidazo<1,2-a>pyridine hydrobromide 
• 69214-09-1 5-bromoimidazo<1,2-a>pyridine 
• 27992-32-1 6-bromo-2-pyridone 
• 171976-37-7 N-(6-bromopyridin-2-yl)-N'-phenylurea 
• 400775-49-7 6-p-Tolyloxy-pyridin-2-ylamine 
• 87779-02-0 2-chloromethyl-5-chloro-4H-pyrido<1,2-a>pyrimidin-4-one 

Relevant articles and documents

PROCESS FOR PREPARATION OF LASMIDITAN

The present invention relates to a process for the preparation of lasmiditan, a compound of formula I, or pharmaceutically acceptable salts thereof, the process comprising reacting a compound of formula IX with N-methoxymethylamine or salt thereof to obtain a compound of formula VII; reacting the compound of formula VII with a compound of formula XIV to obtain lasmiditan or salts thereof.

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Non-deprotonative primary and secondary amination of (hetero)arylmetals

Herein we disclose a novel method for the facile transfer of primary (-NH2) and secondary amino groups (-NHR) to heteroaryl-as well as arylcuprates at low temperature without the need for precious metal catalysts, ligands, excess reagents, protecting and/or Erecting groups. This one-pot transformation allows unprecedented functional group tolerance and it is wellsuited for the amination of electron-rich, electron-deficient as well as structurally complex (hetero)arylmetals. In some of the cases, only catalytic amounts of a copper (l) salt is required.