7450-05-7

Basic information

• Product Name: Cyclohexanol, 4-(trimethylsilyl)-, cis-
• CAS NO: 7450-05-7
• Molecular Formula: C9H20OSi
• Molecular Weight: 172.343
• Mol File: 7450-05-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 4-(trimethylsilyl)-, cis-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 4-(trimethylsilyl)-, cis-(7450-05-7)
• EPA Substance Registry System: Cyclohexanol, 4-(trimethylsilyl)-, cis-(7450-05-7)

Safety Data

• Hazardous Substances Data: 7450-05-7(Hazardous Substances Data)

Upstream product

• 13132-25-7 4-(trimethylsilyl)phenol 
• 877-68-9 4-trimethylsilylanisole 
• 7452-95-1 4-trimethylsilylcyclohexan-1-one 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 18388-87-9 trimethyl-(cis-4-trimethylsilanyloxy-cyclohexyl)-silane 

Downstream Products

• 1544658-04-9 4-((6-(trans-4-(trimethylsilyl)cyclohexyloxy)naphthalen-2-yl)methylamino)bicyclo[2.2.2]octane-1-carboxylic acid 
• 1544662-52-3 methyl 4-((6-(trans-4-(trimethylsilyl)cyclohexyloxy)naphthalen-2-yl)methylamino)bicyclo[2.2.2]octane-1-carboxylate 
• 1544662-48-7 cis-4-(trimethylsilyl)cyclohexyl methanesulfonate 
• 1621065-08-4 ethyl 1-((4-methyl-2-((trans-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621065-07-3 1-((4-methyl-2-((trans-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylic acid 

Relevant articles and documents

Trans-Selective and Switchable Arene Hydrogenation of Phenol Derivatives

A trans-selective arene hydrogenation of abundant phenol derivatives catalyzed by a commercially available heterogeneous palladium catalyst is reported. The described method tolerates a variety of functional groups and provides access to a broad scope of trans-configurated cyclohexanols as potential building blocks for life sciences and beyond in a one-step procedure. The transformation is strategically important because arene hydrogenation preferentially delivers the opposite cis-isomers. The diastereoselectivity of the phenol hydrogenation can be switched to the cis-isomers by employing rhodium-based catalysts. Moreover, a protocol for the chemoselective hydrogenation of phenols to cyclohexanones was developed.

COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS

Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).