7452-95-1

Basic information

• Product Name: 4-(Trimethylsilyl)cyclohexanone
• Synonyms: 4-(Trimethylsilyl)cyclohexanone
• CAS NO: 7452-95-1
• Molecular Formula: C₉H₁₈OSi
• Molecular Weight: 170.32412
• Mol File: 7452-95-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 213.2 °C at 760 mmHg
• Flash Point: 82.8 °C
• Appearance: /
• Density: 0.88 g/cm³
• CAS DataBase Reference: 4-(Trimethylsilyl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trimethylsilyl)cyclohexanone(7452-95-1)
• EPA Substance Registry System: 4-(Trimethylsilyl)cyclohexanone(7452-95-1)

Safety Data

• Hazardous Substances Data: 7452-95-1(Hazardous Substances Data)

Usage

General Description

4-(Trimethylsilyl)cyclohexanone is a chemical compound with the molecular formula C10H20OSi. It is a cyclic ketone derivative that contains a trimethylsilyl group attached to the cyclohexanone ring. 4-(Trimethylsilyl)cyclohexanone is often used as a building block in organic synthesis and as a precursor for the synthesis of various pharmaceuticals and agrochemicals. It is known for its reactivity and versatile applications in the field of organic chemistry. Additionally, 4-(Trimethylsilyl)cyclohexanone is commonly used as a protecting group for alcohols and a reactive intermediate in various chemical reactions.

Upstream product

• 13132-25-7 4-(trimethylsilyl)phenol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 877-68-9 4-trimethylsilylanisole 
• 6793-92-6 p-benzyloxyphenylbromide 
• 195141-02-7 C₁₆H₂₀OSi 

Downstream Products

• 7452-94-0 (trans)-4-(trimethylsilyl)cyclohexanol 
• 1138530-06-9 trimethyl(4-methylenecyclohexyl)silane 
• 910308-84-8 C₁₃H₁₈N₂SSi 
• 7450-05-7 cis-4-(trimethylsilyl)cyclohexanol 
• 1544658-04-9 4-((6-(trans-4-(trimethylsilyl)cyclohexyloxy)naphthalen-2-yl)methylamino)bicyclo[2.2.2]octane-1-carboxylic acid 
• 1544662-48-7 cis-4-(trimethylsilyl)cyclohexyl methanesulfonate 
• 1544662-52-3 methyl 4-((6-(trans-4-(trimethylsilyl)cyclohexyloxy)naphthalen-2-yl)methylamino)bicyclo[2.2.2]octane-1-carboxylate 
• 1621065-08-4 ethyl 1-((4-methyl-2-((trans-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621065-09-5 1-((4-methyl-2-((cis-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylic acid 
• 1621065-10-8 ethyl 1-((4-methyl-2-((cis-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621065-07-3 1-((4-methyl-2-((trans-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylic acid 

Relevant articles and documents

Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

S1P MODULATING AGENTS

Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G()y) dimers.

S1P MODULATING AGENTS

Compounds of formula (I) or (II) can modulate the activity of SIP receptors.