74510-49-9Relevant articles and documents
TOTAL SYNTHESIS OF MAYTANSINOIDS. APPROACH TO 4,6-BISDEMETHYLMAYTANSINE AND 4-DEMETHYLMAYTANSINE
Benechie, Michel,Delpech, Bernard,Khuong-Huu, Qui,Khuong-Huu, Francoise
, p. 1895 - 1910 (2007/10/02)
A convergent strategy was elaborated to synthesize maytansine 1 and maytansinoids modified on the carbon skeleton, especially 4-demethylmaytansine 2, 6-demethylmaytansine 3, 4,6-bisdemethylmaytansine 4.In this paper, the feasibility of the project was verified by the preparation of key intermediates for the synthesis of 4,6-bisdemethylmaytansine and 6-demethylmaytansine.The C-1-N open chain compound 18 in the 4,6-bisdemethyl series was obtained.
Stereocontrolled Total Synthesis of (+/-)-Maytansinol
Isobe, Minoru,Kitamura, Masato,Goto, Toshio
, p. 4997 - 4999 (2007/10/02)
-