7458-08-4

Basic information

• Product Name: N-nitrosodihydrodibenzazepine
• Synonyms: N-nitrosodihydrodibenzazepine;5-Nitroso-10,11-dihydro-5H-dibenzo[b,f]azepine;Einecs 231-232-2
• CAS NO: 7458-08-4
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 0
• EINECS: 231-232-2
• Mol File: 7458-08-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 383.3°C at 760 mmHg
• Flash Point: 185.6°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 4.44E-06mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: N-nitrosodihydrodibenzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: N-nitrosodihydrodibenzazepine(7458-08-4)
• EPA Substance Registry System: N-nitrosodihydrodibenzazepine(7458-08-4)

Safety Data

• Hazardous Substances Data: 7458-08-4(Hazardous Substances Data)

Usage

Uses

N-Nitrosoiminodibenzyl is an N-nitroso derivative of 10,11-Dihydro-5H-dibenzo[b,f]azepine (D448870), which is a metabolite of the tricyclic antidepressant, Imipramine (I465980). 10,11-Dihydro-5H-dibenzo[b,f]azepine can be used as a chromogenic probe for the quantification of hydrogen peroxide and glucose. N-Nitrosoiminodibenzyl can be used as antidepressives and antiepileptics.

InChI:InChI=1/C14H12N2O/c17-15-16-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)16/h1-8H,9-10H2

Upstream product

• 494-19-9 9,10-dihydrodibenzazepine 
• 110-46-3 isopentyl nitrite 

Downstream Products

• 77533-92-7 2-nitro-5-(3'-dimethylaminopropyl)-10,11-dihydro-5H-dibenzazepine 

Relevant articles and documents

Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.

PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis

PS-SNAP was designed and evaluated as a practical nitrosating polymer-supported reagent for the nitrosation of sec-amines. Nitrosated dialkyl amines, alkyl anilines, and bis-anilines were obtained in good yields and high purities after shaking the corresponding amines in the presence of an excess of the newly described reagent followed by simple filtration and removal of solvents.