74628-44-7Relevant articles and documents
Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation
Sato, Mizuho,Murakami, Kazuma,Uno, Mayumi,Ikubo, Haruko,Nakagawa, Yu,Katayama, Sumie,Akagi, Ken-Ichi,Irie, Kazuhiro
, p. 1100 - 1103 (2013/07/27)
Silymarin, the seed extract of Silybium marianum, has preventive effects against Alzheimer's disease-like pathogenesis in vivo. We isolated (+)-taxifolin (4) from silymarin as an inhibitor of aggregation of the 42- residue amyloid -protein. Structure-activity relationship studies revealed the 30,40-dihydroxyl groups to be critical to the anti-aggregative ability, whereas the 7-hydroxyl group and the stereochemistry at positions 2 and 3 were not important.
Photochemical Deoxygenation of an α-Ketol: The Dihydroflavonol-Flavanone Conversion
Westhuizen, Jan H. van der,Ferreira, Daneel,Roux, David G.
, p. 1003 - 1006 (2007/10/02)
Irradiation of optically pure 2,3-trans-3-hydroxyflavanones in anhydrous ethyl acetate leads directly to free phenolic flavanone analogues with complete retention of configuration at C(2).Similarly their methyl ethers give the corresponding flavanones and flavones.The reaction represents the photochemical equivalent of a reduction under Clemmensen conditions.
