480-18-2Relevant articles and documents
Acidic hydrolysis of astilbin and its application for the preparation of taxifolin from Rhizoma Smilacis Glabrae
Qiu, Xiao-Lin,Zhang, Qing-Feng
, p. 290 - 294 (2020/12/01)
The acidic hydrolysis of astilbin to produce its aglycone, taxifolin, was investigated in this study. The effects of aq. HCl concentration and temperature on the reaction were studied, and the kinetic parameters were calculated. The results showed that with higher aq. HCl concentration and temperature, the hydrolysis of astilbin became faster. The activation energy of the hydrolysis reaction under 1 mol L?1 aq. HCl was calculated with a value of 148.6 kJ mol?1. The reaction was successfully applied to produce taxifolin from a sample of Rhizoma Smilacis Glabrae. A simple method for the purification of taxifolin from Rhizoma Smilacis Glabrae was developed with purity of 97.5%.
Total Synthesis of the Natural Products Ulmoside A and (2 R,3 R)-Taxifolin-6- C -β- d -glucopyranoside
Batchu, Venkateswara Rao,Dorigundla, Aravind Reddy,Gurrapu, Raju,Macha, Lingamurthy,Vanka, Umamaheswara Sarma
, p. 1097 - 1101 (2020/07/03)
An efficient first total synthesis of highly polar ulmoside A and (2 R,3 R)-taxifolin-6- C -β- d -glucopyranoside, useful for the prevention of metabolic disorders, has been described. Key elements of the synthesis include a Sc(OTf) 3-catalyzed regio- and stereoselective C -glycosidation on taxifolin in 35percent yield with d -glucose and chiral semipreparative reverse-phase high-performance liquid chromatography (HPLC) for the separation of both taxifolins and the diastereomeric mixture of taxifolin-6- C -β- d -glucopyranosides. Correlation of the analytical data of synthetic ulmoside A and its diastereomer with a natural ulmoside A sample confirmed the assigned absolute stereochemistry of the natural products.
Taxifolin preparation method
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Paragraph 0039-0044; 0049-0054; 0059-0064; 0065; 0069-0074, (2019/03/08)
The invention relates to a method for synthesizing a raw material medicine, in particular to a taxifolin preparation method, aiming to solve the technical problems that waste of plant resources and solvents is great during separation and purification of taxifolin from plants, complete synthesis methods of the taxifolin have long synthetic routes, many complicated raw ingredients are involved, theoverall yield is low and the methods are not suitable for industrial production in the prior art. The taxifolin preparation method has the advantages that dihydromyricetin is selected as a starting material, a crude taxifolin product is obtained by hydrolysis and catalysis closed-loop two-step reactions, and a qualified refined taxifolin product is obtained through purification and refining; the raw material is easy to obtain, the operation is simple, the cost is low, environment friendliness and small pollution are realized, and the taxifolin preparation method is suitable for industrial production.