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Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Taxifolin 480-18-2

Cas:480-18-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Nanjing Spring & Autumn Biological Engineering Co., Ltd. Which was founded at 2008, has an R & D team composed very experienced natural products chemists. The company is a high-tech enterprise engaged in functional health care products raw ma

Taxifolin

Cas:480-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Taxifolin Manufacturer/High quality/Best price/In stock

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

(+-)-taxifolin Test/Observation Specifications Result Appearance White powder to brown powder Complies L

(+-)-taxifolin

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $600.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Taxifolin CAS NO.480-18-2

Cas:480-18-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Taxifolin Cas 480-18-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Yellow powder Storage:Store below -20°C Package:1g/foill bag Application:As medi

Factory supply Taxifolin Cas 480-18-2 with high quality and best price

Cas:480-18-2

Min.Order:1 Gram

FOB Price: $180.0 / 182.0

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,

Hot Sale Larch Extract Dihydroquercetin Powder 98%

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $0.1 / 1.0

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

Taxifolin CAS No.:480-18-2 Name: Taxifolin Synonyms: (2R,3R)-3,3',4',5,7-Pentahydroxyflavanone; (2R,3R)-Dihydroquercetin Molecular Structure: Molecular Formula: C15H12O7 Molecular Weight: 304.25 CAS

High purity Taxifolin CAS No.:480-18-2

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Taxifolin

Cas:480-18-2

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% Taxifolin 480-18-2 HACCP Manufacturer

Cas:480-18-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Taxifolin

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Dihydroquercetin Name:Dihydroquercetin CAS no: 480-18-2 Grade:It is suitable for food, cosmetics, industry, medicine, feed and other industries molecular formula: c15h12o7 molecular weight: 304.25 Product Quality 12 years of

Dihydroquercetin/cas:480-18-2/Dihydroquercetin material

Cas:480-18-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Natural Larch Extract Dihydroquercetin Powder CAS 480-18-2 Taxifolin

Cas:480-18-2

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 480-18-2 with competitive price

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(+)-taxifolin

Cas:480-18-2

Min.Order:10 Kilogram

FOB Price: $160.0 / 200.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

TaxifolinCAS480-18-2

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 22.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Taxifolin/ LIDE PHARMA- Factory supply / Best price

Cas:480-18-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: (+-)-taxifolin Synonyms: (+/-)-Taxifolin anhydrous CAS:480-18-2 MF: C15H12O7 Appearance: Light yellow powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Nutrition Enhancers Transportation:By sea

(+-)-taxifolin

Cas:480-18-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:white to light yellow powder Storage:Room temperature Package:1kg/bag Application:anti-oxidation Transportation:Express/Sea/Air Port:Any port in china

Factory Supply Natural Extract Taxifolin Dihydroquercetin

Cas:480-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)- 480-18-2

Cas:480-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Quality API 99% purity Taxifolin powder pure Taxifolin raw Powder

Cas:480-18-2

Min.Order:10 Gram

FOB Price: $0.6

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At pres

An antioxidant Taxifolin CAS:480-18-2

Cas:480-18-2

Min.Order:1 Gram

FOB Price: $9.5 / 11.8

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Taxifolin CAS: 480-18-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Taxifolin CAS: 480-18-2

Cas:480-18-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Taxifolin

Cas:480-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Hot selling high quality Taxifolin with reasonable price and fast delivery

Cas:480-18-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 480-18-2 Taxifolin

Cas:480-18-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:480-18-2

Cas:480-18-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Dihydroquercetin (taxifolin)

Cas:480-18-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

TAXIFOLIN

Cas:480-18-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,3',4',5,7-Pentahydroxyflavone

Cas:480-18-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one
574749-31-8

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In tetrahydrofuran; methanol at 20℃; for 24h;90%
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol for 48h; Inert atmosphere;85%
catechin
154-23-4

catechin

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: K2CO3 / dimethylformamide / 3 h / 130 °C
1.2: 81 percent / NaH / dimethylformamide / 3 h / 20 °C
2.1: 85 percent / Pb3O4 / benzene / 3 h / 75 - 80 °C
3.1: 90 percent / K2CO3 / methanol; tetrahydrofuran / 2 h / 20 °C
4.1: 85 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; MgSO4 / CH2Cl2 / 3 h / 20 °C
5.1: 90 percent / H2 / Pd/C / methanol; tetrahydrofuran / 24 h / 20 °C
View Scheme
With extract of Burkholderia oxyphila OX-01, Japan, Tsukuba, acidic forest soil In aq. phosphate buffer at 28℃; for 3h; pH=7;
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; 1,4-dioxane; water / 8 h / 0 - 20 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 48 h / Inert atmosphere
View Scheme
(2R,3R)-5,7,3',4'-tetrahydroxyflavanonol 2"-acetylrhamnoside
1298135-47-3

(2R,3R)-5,7,3',4'-tetrahydroxyflavanonol 2"-acetylrhamnoside

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With sulfuric acid In 1,4-dioxane at 100℃; for 1h;
C17H16O8

C17H16O8

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With hydrogenchloride at 55℃; for 0.5h; pH=< 1;55%
taxifolin O-α-D-glucoside
1235442-81-5

taxifolin O-α-D-glucoside

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With water; Saccharomyces cerevisiae α-glucosidase at 30℃; for 18h; pH=7.3; Enzymatic reaction; Potassium phosphate buffer;
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol
490-46-0

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With extract of Burkholderia oxyphila OX-01, Japan, Tsukuba, acidic forest soil In aq. phosphate buffer at 30℃; for 3h; pH=7;
1-(3,4-dihydroxy)phenyl-2-(2,4,6-trihydroxy)phenylethylene oxide

1-(3,4-dihydroxy)phenyl-2-(2,4,6-trihydroxy)phenylethylene oxide

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 5℃; for 5h; Large scale;41.3 kg
1-(2',4',6'-trihydroxyphenyl)-2-hydroxyethanone
55313-03-6

1-(2',4',6'-trihydroxyphenyl)-2-hydroxyethanone

3,4-dihydroxybenzaldehyde
139-85-5

3,4-dihydroxybenzaldehyde

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Stage #1: 1-(2',4',6'-trihydroxyphenyl)-2-hydroxyethanone; 3,4-dihydroxybenzaldehyde With rac-Pro-OH In tetrahydrofuran at 85 - 100℃; for 6h;
Stage #2: With acetic acid In tetrahydrofuran at 20℃; for 2h; Solvent; Temperature;
36.7 g
Conditions
ConditionsYield
With hydrogenchloride In methanol at 50℃; for 0.333333h;82%
Conditions
ConditionsYield
With sulfuric acid; water for 2h; Hydrolysis; Heating;70%
With hesperidinase In water at 37℃; for 36h;37 mg
With hydrogenchloride; water In methanol at 80℃; for 0.75h; Kinetics; Activation energy; Temperature; Concentration;
3,3',4',5,7-pentahydroxy flavanone
215257-15-1

3,3',4',5,7-pentahydroxy flavanone

A

(2S,3S)-taxifolin 3-O-β-D-glucoside
480-18-2, 24198-97-8, 98006-93-0, 114761-89-6, 111003-33-9

(2S,3S)-taxifolin 3-O-β-D-glucoside

B

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With DAICEL CHIRALPAK IA In ethanol; hexane Resolution of racemate;
trans-taxifolin 3-O-α-L-arabinofuranoside

trans-taxifolin 3-O-α-L-arabinofuranoside

A

L-arabinose
5328-37-0

L-arabinose

B

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With hesperidase In water at 37℃; for 456h; enzimatic hydrolysis;A 23 mg
B 48 mg
With hydrogenchloride In water at 50℃; for 16h;A 15 mg
B 32 mg
(2R,3S)-3,5,7-tris(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)chroman
85443-49-8

(2R,3S)-3,5,7-tris(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)chroman

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / Pb3O4 / benzene / 3 h / 75 - 80 °C
2: 90 percent / K2CO3 / methanol; tetrahydrofuran / 2 h / 20 °C
3: 85 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; MgSO4 / CH2Cl2 / 3 h / 20 °C
4: 90 percent / H2 / Pd/C / methanol; tetrahydrofuran / 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; 1,4-dioxane; water / 8 h / 0 - 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 48 h / Inert atmosphere
View Scheme
(+)-3',4',3,5,7-penta-O-benzyl-(4S)-hydroxycatechine
574749-29-4

(+)-3',4',3,5,7-penta-O-benzyl-(4S)-hydroxycatechine

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; MgSO4 / CH2Cl2 / 3 h / 20 °C
2: 90 percent / H2 / Pd/C / methanol; tetrahydrofuran / 24 h / 20 °C
View Scheme
(+)-(4S)-acetoxy-3',4',3,5,7-penta-O-benzylcatechine
478241-14-4

(+)-(4S)-acetoxy-3',4',3,5,7-penta-O-benzylcatechine

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / K2CO3 / methanol; tetrahydrofuran / 2 h / 20 °C
2: 85 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; MgSO4 / CH2Cl2 / 3 h / 20 °C
3: 90 percent / H2 / Pd/C / methanol; tetrahydrofuran / 24 h / 20 °C
View Scheme
3,5-dihydroxyphenol
108-73-6

3,5-dihydroxyphenol

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / dichloromethane / 2 h / 5 - 10 °C / Large scale
1.2: 4 h / 10 - 20 °C / Large scale
2.1: 3-chloro-benzenecarboperoxoic acid / methanol / 4 h / 5 - 15 °C / Large scale
3.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 5 °C / Large scale
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
1.2: 5 h / -5 °C / Inert atmosphere
2.1: trifluoromethylsulfonic anhydride / dichloromethane / 0.08 h / -5 °C / Inert atmosphere
2.2: -5 °C / Inert atmosphere
3.1: sodium hydroxide; dihydrogen peroxide / methanol / 5 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / methanol; water; tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
5.1: Resolution of racemate
View Scheme
(2R,3R)-taxifolin 3-β-D-glucopyranoside 6''-gallate

(2R,3R)-taxifolin 3-β-D-glucopyranoside 6''-gallate

A

3,4,5-trihydroxybenzoic acid
149-91-7

3,4,5-trihydroxybenzoic acid

B

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With sulfuric acid In ethanol; water for 3h; Heating;A 12 mg
B 32 mg
(E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(2,4,6-tris(methoxymethoxy)phenyl)-prop-2-en-1-one
36804-12-3

(E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(2,4,6-tris(methoxymethoxy)phenyl)-prop-2-en-1-one

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; dihydrogen peroxide / methanol / 5 h / 20 °C / Inert atmosphere
2: hydrogenchloride / methanol; water; tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
3: Resolution of racemate
View Scheme
(+/-)-2,3-trans-2,3-epoxy-1-2",4",6"-tris(methoxymethoxy)phenyl-3-3',4'-bis(methoxymethoxy)phenylpropanone

(+/-)-2,3-trans-2,3-epoxy-1-2",4",6"-tris(methoxymethoxy)phenyl-3-3',4'-bis(methoxymethoxy)phenylpropanone

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / methanol; water; tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
2: Resolution of racemate
View Scheme
caffeic acid
331-39-5

caffeic acid

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sulfuric acid / methanol / 1 h / 20 °C / Inert atmosphere
1.2: 0 °C / Inert atmosphere
2.1: sodium hydroxide / methanol; tetrahydrofuran / Inert atmosphere
3.1: trifluoromethylsulfonic anhydride / dichloromethane / 0.08 h / -5 °C / Inert atmosphere
3.2: -5 °C / Inert atmosphere
4.1: sodium hydroxide; dihydrogen peroxide / methanol / 5 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride / methanol; water; tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
6.1: Resolution of racemate
View Scheme
5,7,3',4'-tetra-O-benzyl-(+)-catechin
20728-73-8

5,7,3',4'-tetra-O-benzyl-(+)-catechin

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; 1,4-dioxane; water / 8 h / 0 - 20 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 48 h / Inert atmosphere
View Scheme
1,3,5-tris(methoxymethoxy)benzene
120677-47-6

1,3,5-tris(methoxymethoxy)benzene

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trifluoromethylsulfonic anhydride / dichloromethane / 0.08 h / -5 °C / Inert atmosphere
1.2: -5 °C / Inert atmosphere
2.1: sodium hydroxide; dihydrogen peroxide / methanol / 5 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / methanol; water; tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
4.1: Resolution of racemate
View Scheme
(E)-3-(3,4-bis(methoxymethoxy)phenyl)acrylic acid
850177-05-8

(E)-3-(3,4-bis(methoxymethoxy)phenyl)acrylic acid

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: trifluoromethylsulfonic anhydride / dichloromethane / 0.08 h / -5 °C / Inert atmosphere
1.2: -5 °C / Inert atmosphere
2.1: sodium hydroxide; dihydrogen peroxide / methanol / 5 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / methanol; water; tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
4.1: Resolution of racemate
View Scheme
C15H20O7

C15H20O7

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / methanol; tetrahydrofuran / Inert atmosphere
2.1: trifluoromethylsulfonic anhydride / dichloromethane / 0.08 h / -5 °C / Inert atmosphere
2.2: -5 °C / Inert atmosphere
3.1: sodium hydroxide; dihydrogen peroxide / methanol / 5 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / methanol; water; tetrahydrofuran / 2 h / 55 °C / Inert atmosphere
5.1: Resolution of racemate
View Scheme
(R)-3,5,7-Trihydroxy-2-[4-hydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chroman-4-one

(R)-3,5,7-Trihydroxy-2-[4-hydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chroman-4-one

A

D-glucose
50-99-7

D-glucose

C

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With pectinase In water Ambient temperature;A n/a
B 20 mg
C 3 g
Conditions
ConditionsYield
With acetic acid In water; acetonitrile Resolution of racemate;
Resolution of racemate;
(+)-taxifolin 3-O-β-D-xylopyranoside
40672-47-7

(+)-taxifolin 3-O-β-D-xylopyranoside

A

D-xylose
58-86-6

D-xylose

B

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
In water at 37℃; for 1h; hesperidinase; Yield given. Yields of byproduct given;
(2R,3R)-(+)-dihydroquercetin-3-β-D-glucopyranoside
27297-45-6

(2R,3R)-(+)-dihydroquercetin-3-β-D-glucopyranoside

A

D-glucose
50-99-7

D-glucose

B

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
With sulfuric acid In ethanol for 2h; Heating;A n/a
B 48 mg
caffeic acid chloride
23416-69-5

caffeic acid chloride

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / dichloromethane / 2 h / 5 - 10 °C / Large scale
1.2: 4 h / 10 - 20 °C / Large scale
2.1: 3-chloro-benzenecarboperoxoic acid / methanol / 4 h / 5 - 15 °C / Large scale
3.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 5 °C / Large scale
View Scheme
2,4,6-trihydroxyacetophenone
480-66-0

2,4,6-trihydroxyacetophenone

taxifolin
480-18-2

taxifolin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 2 h / 5 °C
1.2: 4 h / 25 °C
2.1: dihydrogen peroxide / tetrahydrofuran; water / 4 h / 25 °C
3.1: hydrogenchloride / 0.5 h / 55 °C / pH < 1
View Scheme
n-octanoic acid chloride
111-64-8

n-octanoic acid chloride

taxifolin
480-18-2

taxifolin

taxifolin tetra-octanoate

taxifolin tetra-octanoate

Conditions
ConditionsYield
Stage #1: n-octanoic acid chloride; taxifolin In 1,4-dioxane at 20℃; for 0.166667h;
Stage #2: With pyridine In 1,4-dioxane at 20℃; for 16h;
86%
Stage #1: n-octanoic acid chloride; taxifolin In 1,4-dioxane at 20℃; for 0.166667h;
Stage #2: With pyridine In 1,4-dioxane for 16h;
79%
taxifolin
480-18-2

taxifolin

taxifolin 4'-O-sulfate

taxifolin 4'-O-sulfate

Conditions
ConditionsYield
With p-nitrophenyl sulfate; arylsulfate sulfotransferase from Desulfitobacterium hafniense In acetone at 30℃; for 4h; pH=8.9; Inert atmosphere; Enzymatic reaction;75%
1-deoxy-1-fluoro-α-D-glucose
2106-10-7

1-deoxy-1-fluoro-α-D-glucose

taxifolin
480-18-2

taxifolin

taxifolin 7-α-O-glucoside

taxifolin 7-α-O-glucoside

Conditions
ConditionsYield
With α-glucosidase from sulfolobus solfataricus In dimethyl sulfoxide at 45℃; for 2h; pH=9; Enzymatic reaction;99%
water
7732-18-5

water

copper(II) sulfate
7758-99-8

copper(II) sulfate

taxifolin
480-18-2

taxifolin

C15H14CuO9

C15H14CuO9

Conditions
ConditionsYield
With ammonia In ethanol at 20℃; for 1h; pH=5 - 7; Temperature;86.3%
catechin
154-23-4

catechin

taxifolin
480-18-2

taxifolin

procyanidin B3
23567-23-9

procyanidin B3

Conditions
ConditionsYield
With sodium tetrahydroborate; acetic acid In ethanol; water for 0.5h; pH=4.5; Inert atmosphere;22%
With sodium tetrahydroborate; water; acetic acid 1.) EtOH, 30 min, 2.) EtOH; Multistep reaction;
With sodium tetrahydroborate In ethanol Inert atmosphere;
Stage #1: taxifolin With sodium tetrahydroborate; ethanol at 20℃; for 0.75h;
Stage #2: catechin With hydrogenchloride In water for 1h;
200 mg
taxifolin
480-18-2

taxifolin

2,3-trans-flavan-3,4-diol
480-17-1

2,3-trans-flavan-3,4-diol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20℃; for 1h;
Stage #1: taxifolin With sodium tetrahydroborate In ethanol at 20℃; for 1h;
Stage #2: for 0.5h;
taxifolin
480-18-2

taxifolin

(+)-(2R,3S,4S)-3,4,5,7,3',4'-hexahydroxyflavan
93527-39-0

(+)-(2R,3S,4S)-3,4,5,7,3',4'-hexahydroxyflavan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaBH4 / ethanol / 2 h / Ambient temperature
2: 0.05 M citrate-Pi buffer, pH 2.6 / 0.5 h / 40 °C
View Scheme
With NADPH In aq. buffer at 45℃; for 0.5h; pH=6; Enzymatic reaction;
taxifolin
480-18-2

taxifolin

(2R,3S,4R)-(+)-3,4,5,7,3',4'-hexahydroxyflavan
69256-15-1

(2R,3S,4R)-(+)-3,4,5,7,3',4'-hexahydroxyflavan

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 20℃; for 2h;75%
With sodium tetrahydroborate In ethanol for 2h; Ambient temperature;
With sodium tetrahydroborate In ethanol for 2h;
water
7732-18-5

water

copper diacetate
142-71-2

copper diacetate

taxifolin
480-18-2

taxifolin

C15H14CuO9

C15H14CuO9

Conditions
ConditionsYield
In ethanol at 20℃; for 1h;86.3%
6-[(2-aminopropyl)amino]-6-deoxy-β-cyclodextrin
131991-59-8

6-[(2-aminopropyl)amino]-6-deoxy-β-cyclodextrin

taxifolin
480-18-2

taxifolin

C15H12O7*C45H78N2O34

C15H12O7*C45H78N2O34

Conditions
ConditionsYield
In ethanol at 45℃; for 72h;64%
zinc(II) acetate dihydrate
5970-45-6

zinc(II) acetate dihydrate

taxifolin
480-18-2

taxifolin

Zn(2+)*2C15H11O7(1-)*2H2O

Zn(2+)*2C15H11O7(1-)*2H2O

Conditions
ConditionsYield
In water at 92℃; for 0.4h; Time; Industrial scale;84%
acetic anhydride
108-24-7

acetic anhydride

taxifolin
480-18-2

taxifolin

2-(3,4-diacetoxyphenyl)-4-oxochroman-3,5,7-triyl triacetate
6685-67-2, 70497-17-5, 132487-23-1

2-(3,4-diacetoxyphenyl)-4-oxochroman-3,5,7-triyl triacetate

Conditions
ConditionsYield
With pyridine for 18h; Ambient temperature;88%
With pyridine at 90℃; for 3h; Acetylation;47%
In pyridine
(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol
490-46-0

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol

taxifolin
480-18-2

taxifolin

procyanidin B4
29106-51-2

procyanidin B4

Conditions
ConditionsYield
With sodium tetrahydroborate
Stage #1: taxifolin With sodium tetrahydroborate; ethanol at 20℃; for 0.75h;
Stage #2: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol With hydrogenchloride In water for 1h;
200 mg
D-Glucose
2280-44-6

D-Glucose

taxifolin
480-18-2

taxifolin

(2R,3R)-(+)-3',4',5,7-tetrahydroxydihydroflavonol-6-C-β-D-glucopyranoside
112494-39-0

(2R,3R)-(+)-3',4',5,7-tetrahydroxydihydroflavonol-6-C-β-D-glucopyranoside

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) In water; acetonitrile for 48h; Reagent/catalyst; Solvent; Inert atmosphere; Reflux; stereoselective reaction;35%
taxifolin
480-18-2

taxifolin

6,8-dibromodihydroquercetin

6,8-dibromodihydroquercetin

Conditions
ConditionsYield
With N-Bromosuccinimide In acetone at 25℃; for 0.716667h; regiospecific reaction;94%
With 2,3-dibromo-3-phenylpropanoic acid; potassium carbonate In N,N-dimethyl-formamide at 60℃; for 16h; Inert atmosphere;46%
With hypobromous acid In ethanol; water at 20℃; aq. phosphate buffer;
taxifolin
480-18-2

taxifolin

(E/Z)-3,7-dimethyl-2,6-octadienal
5392-40-5

(E/Z)-3,7-dimethyl-2,6-octadienal

C26H30O7

C26H30O7

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol at 120 - 130℃; for 10h; Temperature;70 g
α-lipoic acid chloride
387358-39-6

α-lipoic acid chloride

taxifolin
480-18-2

taxifolin

2-(3,4-bis(5-(1,2-dithiolan-3-yl)pentanoyloxy)phenyl)-4-oxochroman-3,5,7-triyl tris(5-(1,2-dithiolan-3-yl)pentanoate)

2-(3,4-bis(5-(1,2-dithiolan-3-yl)pentanoyloxy)phenyl)-4-oxochroman-3,5,7-triyl tris(5-(1,2-dithiolan-3-yl)pentanoate)

Conditions
ConditionsYield
Stage #1: α-lipoic acid chloride; taxifolin In 1,4-dioxane at 20℃; for 0.116667h;
Stage #2: With pyridine In 1,4-dioxane at 20℃; for 4h;
1.8 g
5-((3R)-1,2-dithiolan-3-yl)pentanoyl chloride
13880-12-1

5-((3R)-1,2-dithiolan-3-yl)pentanoyl chloride

taxifolin
480-18-2

taxifolin

2-(3,4-bis(5-(1,2-dithiolan-3-yl)pentanoyloxy)phenyl)-4-oxochroman-3,5,7-triyl tris(5-(1,2-dithiolan-3-yl)pentanoate)

2-(3,4-bis(5-(1,2-dithiolan-3-yl)pentanoyloxy)phenyl)-4-oxochroman-3,5,7-triyl tris(5-(1,2-dithiolan-3-yl)pentanoate)

Conditions
ConditionsYield
Stage #1: 5-((3R)-1,2-dithiolan-3-yl)pentanoyl chloride; taxifolin In 1,4-dioxane at 20℃; for 0.116667h;
Stage #2: With pyridine In 1,4-dioxane at 20℃; for 19h;
1.8 g
Conditions
ConditionsYield
With apple polyphenol oxidase In aq. phosphate buffer at 35℃; for 1h; pH=4; Enzymatic reaction;
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