Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:480-66-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:480-66-0
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiry2',4',6'-Trihydroxyacetophenone monohydrate Basic information Product Name: 2',4',6'-Trihydroxyacetophenone monohydrate Synonyms: 1-(2,4,6-T
Cas:480-66-0
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:480-66-0
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:480-66-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:480-66-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:480-66-0
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:480-66-0
Min.Order:1 Kilogram
FOB Price: $290.0 / 590.0
Type:Trading Company
inquiryProduct name 2',4',6'-Trihydroxyacetophenone monohydrate CAS NO. 480-66-0 Molecular formula C8H8O4.H2O
Cas:480-66-0
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:480-66-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:480-66-0
Min.Order:1 Kilogram
FOB Price: $100.0 / 120.0
Type:Trading Company
inquiry2',4',6'-Trihydroxyacetophenone monohydrate CAS:480-66-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali
Cas:480-66-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:480-66-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:480-66-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:480-66-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:480-66-0
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:480-66-0
Min.Order:0 Metric Ton
Negotiable
Type:Other
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:480-66-0
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:480-66-0
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:Light Brown Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Induced choleresis in rats is mediated through mu
Cas:480-66-0
Min.Order:100 Gram
Negotiable
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:480-66-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:480-66-0
Min.Order:0
Negotiable
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:480-66-0
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiry2',4',6'-Trihydroxyacetophenone monohydrate Chemical Properties Melting point 219-221 °C(lit.) Boiling point 257.07°C (rough estimate) density 1.3037 (rough estimate) refractive index 1.5090 (estimate) storage temp
Cas:480-66-0
Min.Order:1 Gram
FOB Price: $66.0
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:480-66-0
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:480-66-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:480-66-0
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h
1.Good capacity; 2.Safe deliver 3. High quality with best price Appearance:White Powder Storage:Dry and cool place Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Application:For Pharmaceutical Intermediates Transportation:By DHL, TNT
Cas:480-66-0
Min.Order:10 Gram
Negotiable
Type:Other
inquiryConditions | Yield |
---|---|
Stage #1: 3,5-dihydroxyphenol; acetonitrile With hydrogenchloride; zinc(II) chloride In di-isopropyl ether at 0℃; Stage #2: With water for 2h; Reflux; | 96.2% |
Stage #1: 3,5-dihydroxyphenol; acetonitrile With hydrogenchloride; zinc(II) chloride In diethyl ether at -20℃; for 2h; Stage #2: With water for 2h; Reflux; | 80% |
With hydrogenchloride; zinc(II) chloride In diethyl ether for 6h; Cooling with ice; | 80.7% |
1-(2,4,6-tris((tert-butyldimethylsilyl)oxy)phenyl)ethan-1-one
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethylguanidine In acetonitrile at 50℃; for 1h; | 92% |
Conditions | Yield |
---|---|
With 4-chlorophenylethylamine; copper(I) bromide at 5℃; for 35h; Temperature; Reflux; | 92% |
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In ethyl acetate at 40℃; for 10h; | 90% |
With boron trifluoride diethyl etherate In ethyl acetate at 40℃; for 10h; | 90% |
With boron trifluoride diethyl etherate at 20℃; for 15h; Inert atmosphere; | 88% |
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With water Heating; | 90% |
With water for 3h; Reflux; | 20% |
With water for 3h; Reflux; | 20% |
With water for 1.5h; Heating; | |
In water for 2h; Reflux; |
1-{4-[(tert-butyldimethylsilyl)oxy]-2,6-dihydroxyphenyl}ethan-1-one
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With KF-Al2O3 (basic) In acetonitrile for 18h; Ambient temperature; | 86% |
1-[2,4,6-tris(acetyloxy)phenyl]ethanone
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With water; sodium acetate In ethanol for 5h; Reflux; | 86% |
Conditions | Yield |
---|---|
With carbon disulfide; aluminum (III) chloride In nitrobenzene at 20 - 50℃; for 1h; | 85.7% |
Stage #1: 3,5-dihydroxyphenol With aluminum (III) chloride In dichloromethane; nitrobenzene at 0℃; Inert atmosphere; Stage #2: acetyl chloride In dichloromethane; nitrobenzene at 0 - 90℃; for 4h; Inert atmosphere; | 85% |
Stage #1: 3,5-dihydroxyphenol With aluminum (III) chloride In nitrobenzene; 1,2-dichloro-ethane at 0℃; for 0.166667h; Friedel-Crafts Acylation; Inert atmosphere; Stage #2: acetyl chloride In nitrobenzene; 1,2-dichloro-ethane for 5h; Friedel-Crafts Acylation; Inert atmosphere; | 82.5% |
Conditions | Yield |
---|---|
With zinc(II) chloride at 140 - 145℃; for 2h; Friedel Crafts acylation; | 80% |
With boron trifluoride |
1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With triethylammonium formate; palladium on activated charcoal for 2h; Ambient temperature; | 75% |
3,5-dihydroxyphenol
acetic anhydride
A
2,4-diacetylphloroglucinol
B
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With zinc(II) chloride at 145 - 150℃; for 0.25h; | A 25% B 50% |
3,5-dihydroxyphenol
benzene-1,4-diyl diacetate
A
2,4,6-trihydroxyacetophenone
B
2,5-Dihydroxyacetophenone
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In benzene for 0.5h; cross Fries reaction; microwave irradiation; | A 35% B 40% |
acetylacetone
malonic acid dimethyl ester
A
2,4,6-trihydroxyacetophenone
B
methyl orsellinate
Conditions | Yield |
---|---|
With n-butyllithium; sodium hydride In tetrahydrofuran; hexane for 48h; Heating; | A 30% B 8% |
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In benzene for 3h; crossover Friess rearrangement; Heating; | 30% |
3,5-dihydroxyphenol
A
4-methyl-5,7-dihydroxycoumarin
B
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With aluminium trichloride; nitrobenzene; acetyl chloride Erhitzen des Reaktionsprodukts mit wss. Salzsaeure; |
Conditions | Yield |
---|---|
With sodium hydroxide at 25℃; | |
With sodium methylate In methanol |
Conditions | Yield |
---|---|
With sodium hydroxide at 25℃; | |
Multi-step reaction with 2 steps 1: diluted NaOH-solution 2: diluted NaOH-solution / 25 °C View Scheme |
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With water at 160 - 170℃; |
2,4,6-trihydroxyacetophenone
3,5-dihydroxyphenol
acetyl chloride
A
4-methyl-5,7-dihydroxycoumarin
B
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With aluminium trichloride; nitrobenzene Erhitzen des Reaktionsprodukts mit wss.HCl; |
methyl 3,5,7-trioxooctanoate
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With potassium hydroxide |
2-hydroxy-4,6-dimethoxyacetophenone
A
2,4,6-trihydroxyacetophenone
B
4,6-dihydroxy-2-methoxyacetophenone
Conditions | Yield |
---|---|
With aluminium trichloride In chlorobenzene for 1h; Heating; | A 1.6 g B 2.0 g |
3,5-dihydroxyphenol
acetic acid
A
2,4-diacetylphloroglucinol
B
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate at 100℃; for 2h; |
1-(2,4,6-trimethoxyphenyl)ethanone
A
2-hydroxy-4,6-dimethoxyacetophenone
B
2,4,6-trihydroxyacetophenone
C
2,6-dihydroxy-4-methoxy-acetophenone
D
4,6-dihydroxy-2-methoxyacetophenone
Conditions | Yield |
---|---|
With aluminium trichloride In chlorobenzene | A n/a B n/a C n/a D 29 % Chromat. |
Conditions | Yield |
---|---|
With pyridine hydrochloride |
Conditions | Yield |
---|---|
With In methanol; water |
hydrogenchloride
3,5-dihydroxyphenol
diethyl ether
acetonitrile
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
nachfolgend Kochen des Reaktionsproduktes mit Wasser; |
3,5-dihydroxyphenol
Resorcinol diacetate
sulfuric acid
A
2',4'-dihydroxy-4-acetophenone
B
2,4-diacetylphloroglucinol
C
2,4,6-trihydroxyacetophenone
2,4,6-trihydroxyacetophenone
Conditions | Yield |
---|---|
With water |
2,4,6-trihydroxyacetophenone
dimethyl sulfate
2-hydroxy-4,6-dimethoxyacetophenone
Conditions | Yield |
---|---|
With potassium carbonate In acetone Inert atmosphere; | 100% |
With potassium carbonate In acetone for 3h; Reflux; | 100% |
With potassium carbonate In acetone at 66℃; for 2h; Inert atmosphere; | 100% |
Dimethoxymethane
2,4,6-trihydroxyacetophenone
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone
Conditions | Yield |
---|---|
Stage #1: Dimethoxymethane With acetyl chloride; zinc dibromide In dichloromethane at 20 - 30℃; for 3.5h; Stage #2: 2,4,6-trihydroxyacetophenone With N-ethyl-N,N-diisopropylamine In dichloromethane at 5 - 10℃; | 100% |
Stage #1: Dimethoxymethane With acetyl chloride; zinc dibromide at 20℃; for 2h; Inert atmosphere; Stage #2: 2,4,6-trihydroxyacetophenone With diisopropylamine In dichloromethane for 3h; Inert atmosphere; Cooling with ice; regioselective reaction; | 50% |
Stage #1: Dimethoxymethane With acetyl chloride; zinc dibromide In dichloromethane at 20℃; for 3.5h; Stage #2: 2,4,6-trihydroxyacetophenone With N-ethyl-N,N-diisopropylamine In dichloromethane at 5℃; |
2,4,6-trihydroxyacetophenone
tert-butyldimethylsilyl chloride
1-{4-[(tert-butyldimethylsilyl)oxy]-2,6-dihydroxyphenyl}ethan-1-one
Conditions | Yield |
---|---|
Stage #1: 2,4,6-trihydroxyacetophenone; tert-butyldimethylsilyl chloride With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; Stage #2: With pyridinium p-toluenesulfonate In methanol for 4h; Inert atmosphere; Reflux; | 99% |
2,4,6-trihydroxyacetophenone
acetic anhydride
3-Acetyl-5,7-bis(acetyloxy)-2-methyl-4H-1-benzopyran-4-one
Conditions | Yield |
---|---|
With sodium acetate for 9h; Heating; | 98% |
With sodium acetate | |
With sodium acetate for 10h; Heating; | 11.8 g |
With sodium acetate for 10h; Heating / reflux; | |
With sodium acetate for 10h; Heating / reflux; |
dimedone
2,4,6-trihydroxyacetophenone
isobutyraldehyde
2-(1-(3-acetyl-2,4,6-trihydroxy-5-(1-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-2-methylpropyl)phenyl)-2-methylpropyl)-3-hydroxy-5,5-dimethylcyclohex-2-enone
Conditions | Yield |
---|---|
Stage #1: dimedone; isobutyraldehyde With piperidine In dichloromethane at 20℃; for 0.25h; Mannich reaction; Stage #2: With hydrogenchloride; ammonium chloride In water Stage #3: 2,4,6-trihydroxyacetophenone With sodium hydride In tetrahydrofuran at 20℃; for 3h; Friedel Crafts alkylation; | 96% |
2,4,6-trihydroxyacetophenone
acetic anhydride
acetic acid 5-acetoxy-2-acetyl-3-hydroxyphenyl ester
Conditions | Yield |
---|---|
With pyridine; dmap at 60℃; for 3h; | 95% |
With pyridine; dmap at 60℃; for 3h; | 95% |
With pyridine for 5h; Ambient temperature; | 38% |
With pyridine |
2,4,6-trihydroxyacetophenone
chloromethyl methyl ether
2,4,6-tri-MOM phloracetophenone
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.75h; | 95% |
With sodium hydride In N,N-dimethyl-formamide at 85℃; for 4h; Temperature; | 95% |
Stage #1: 2,4,6-trihydroxyacetophenone With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: chloromethyl methyl ether In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.75h; Inert atmosphere; | 83% |
2,4,6-trihydroxyacetophenone
tert-butyldimethylsilyl chloride
1-(2,4,6-tris((tert-butyldimethylsilyl)oxy)phenyl)ethan-1-one
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; silylation; | 95% |
With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 3h; | 91% |
2,4,6-trihydroxyacetophenone
benzyl bromide
1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h; | 95% |
With potassium carbonate In N,N-dimethyl-formamide | 94% |
With potassium carbonate In acetonitrile for 3h; Reflux; | 91% |
Conditions | Yield |
---|---|
With tin(IV) chloride In 1,2-dichloro-ethane Heating; | 95% |
2,4,6-trihydroxyacetophenone
acetyl chloride
3-acetyl-5,7-dihydroxy-2-methyl-chromen-4-one
Conditions | Yield |
---|---|
Stage #1: 2,4,6-trihydroxyacetophenone With potassium carbonate In tetrahydrofuran at 20 - 50℃; for 1h; Stage #2: acetyl chloride In tetrahydrofuran for 4h; Heating / reflux; Stage #3: With hydrogenchloride In tetrahydrofuran; water | 95% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In pyridine at 80 - 90℃; for 7h; | 51% |
bromethyl methyl ether
2,4,6-trihydroxyacetophenone
2,4,6-tri-MOM phloracetophenone
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 3h; | 95% |
Conditions | Yield |
---|---|
With potassium carbonate; dimethyl sulfate In acetone | 94.4% |
With dimethylsulfide; potassium carbonate In acetone at 20℃; |
2,4,6-trihydroxyacetophenone
chloromethyl methyl ether
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone
Conditions | Yield |
---|---|
Stage #1: 2,4,6-trihydroxyacetophenone With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; Inert atmosphere; Stage #2: chloromethyl methyl ether In dichloromethane at 0 - 20℃; | 94% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.25h; Inert atmosphere; | 94% |
With potassium carbonate In acetone Reflux; | 90% |
2,4,6-trihydroxyacetophenone
tert-butyldimethylsilyl chloride
1-(2,4-bis((tert-butyldimethylsilyl)oxy)-6-hydroxyphenyl)-2-ethan-1-one
Conditions | Yield |
---|---|
With 1H-imidazole In N,N-dimethyl-formamide for 0.5h; | 94% |
With 1H-imidazole In N,N-dimethyl-formamide for 2h; | 92% |
With triethylamine In dichloromethane at 20℃; for 1.5h; Inert atmosphere; | 83% |
2,4,6-trihydroxyacetophenone
p-toluenesulfonyl chloride
4-acetyl-5-hydroxy-1,3-phenylene bis(4-methylbenzenesulfonate)
Conditions | Yield |
---|---|
With potassium carbonate In acetone Inert atmosphere; Reflux; | 94% |
With potassium carbonate In acetone for 5h; Reflux; |
Conditions | Yield |
---|---|
With triethylamine In diethyl ether at 7℃; Heating; | 93% |
Conditions | Yield |
---|---|
With ethylenediamine diacetic acid In dichloromethane at 20℃; for 10h; | 93% |
2,4,6-trihydroxyacetophenone
triisopropylsilyl trifluoromethanesulfonate
1-(2-hydroxy-4,6-diisopropylsilyloxyphenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: 2,4,6-trihydroxyacetophenone With triethylamine In dichloromethane; water at -78 - 20℃; Inert atmosphere; Stage #2: triisopropylsilyl trifluoromethanesulfonate In dichloromethane; water at -78℃; for 1h; Inert atmosphere; | 93% |
2,4,6-trihydroxyacetophenone
acetic anhydride
2,4-diacetylphloroglucinol
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; acetic acid for 21h; Heating; | 92% |
With boron trifluoride diethyl etherate at 20℃; for 24h; Acetylation; | 90% |
Stage #1: 2,4,6-trihydroxyacetophenone; acetic anhydride With boron trifluoride diethyl etherate In acetic acid Marchand reaction; Reflux; Stage #2: With sodium hydroxide In methanol for 5h; Stage #3: With hydrogenchloride In methanol; water |
2,4,6-trihydroxyacetophenone
o-chlorobenzoyl chloride
2',4',6'-tris(2-chlorobenzoyloxy)acetophenone
Conditions | Yield |
---|---|
With pyridine; dmap at 20℃; for 3h; | 92% |
2,4,6-trihydroxyacetophenone
methyl trifluoromethanesulfonate
2-hydroxy-4,6-dimethoxyacetophenone
Conditions | Yield |
---|---|
With potassium carbonate In acetone at 0 - 70℃; for 10h; | 92% |
With potassium carbonate In acetone for 3h; Reflux; | 88% |
2-iodo-propane
2,4,6-trihydroxyacetophenone
1-(2-hydroxy-4,6-diisopropoxyphenyl)ethanone
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 10h; Inert atmosphere; | 92% |
2,4,6-trihydroxyacetophenone
ethyl phloroglucinol
Conditions | Yield |
---|---|
With hydrogenchloride; sodium cyanoborohydride In methanol; water for 12h; | 91% |
With amalgamated zinc; ethanol; acetic acid weiteres Reagens: wss. HCl; | |
With hydrogenchloride; sodium cyanoborohydride In methanol for 24h; | 100 % Spectr. |
With dimethylamine borane In tetrahydrofuran for 24h; Heating; |
2,4,6-trihydroxyacetophenone
N,N-dimethyl-formamide
3'-formyl-2',4',6'-trihydroxyacetophenone
Conditions | Yield |
---|---|
Stage #1: 2,4,6-trihydroxyacetophenone; N,N-dimethyl-formamide With trichlorophosphate In ethyl acetate at 20℃; for 1h; Vilsmeier-Haack Formylation; Stage #2: In water; ethyl acetate | 91% |
With trichlorophosphate at 20℃; | 70% |
With trichlorophosphate In ethyl acetate at 20℃; for 1h; Vilsmeier-Haack Formylation; Cooling with ice; | 64.7% |
With trichlorophosphate In ethyl acetate at 20℃; for 0.5h; Vilsmeier-Haack formylation; |
bromethyl methyl ether
2,4,6-trihydroxyacetophenone
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere; | 91% |
Stage #1: bromethyl methyl ether; 2,4,6-trihydroxyacetophenone With N-ethyl-N,N-diisopropylamine In dichloromethane for 0.333333h; Cooling with ice; Stage #2: bromethyl methyl ether In dichloromethane for 12.3h; | 75.5% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 3℃; for 3h; Inert atmosphere; | 74.5% |
With potassium carbonate In acetone for 3h; Heating; | 68% |
With potassium carbonate In acetone for 3h; Reflux; | 68% |
Conditions | Yield |
---|---|
With silica sulphuric acid In neat (no solvent) at 60℃; Friedel-Crafts Acylation; Green chemistry; | 91% |
With methanesulfonic acid; acetic acid In neat (no solvent) at 80℃; for 0.25h; Temperature; Friedel-Crafts Acylation; Inert atmosphere; |
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