Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:108-59-8
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:108-59-8
Min.Order:1 Metric Ton
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inquiryProduct description: Product name Dimethyl malonate CAS number 108-59-8 Assay ≥99.5% Appearance Colorless transparent liquid Capacity 1000mt/year Application Pharmaceutical,
Cas:108-59-8
Min.Order:1 Kilogram
FOB Price: $12.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:108-59-8
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Used in pharmaceutical and organic synthesis Appearance:colorless transparent liquid Storage:Store in a cool, dry, well ventilated warehouse. Package:200kg PE drum or 1000kg IBC tank Application:Used in pharmaceutical and organic synthesis Port:Any
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:108-59-8
Min.Order:1 Gram
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Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Dimethyl malonate CAS 108-59-8 Methyl malonate CAS no 108-59-8 Propanedioic acid dimethyl ester Dimethyl malonate CAS 108-59-8 IN Stock CAS 108-59-8 Methyl malonate Dimethyl malonate COA TDS price MSDS Dimethyl malonate MSDS Product no. chemw
Cas:108-59-8
Min.Order:5 Kiloliter
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Type:Manufacturers
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:108-59-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c
Cas:108-59-8
Min.Order:1 Metric Ton
FOB Price: $2200.0 / 2500.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:108-59-8
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:108-59-8
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
Cas:108-59-8
Min.Order:1 Kilogram
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Type:Trading Company
inquiryProduct name Dimethyl malonate English name Dimethyl malonate Alias Dimethylmalonate; Dimethyl Caroate; Methyl Malonate CAS RN 108-59-8 Molecular weight 132.11612 Molecular formula
Appearance:clear colorless liquid Storage:Store below +30°C. Package:200kg/Drum Application:It is used in fragrances and some artificial flavorings . Transportation:Express/Sea/Air Port:Any port in China
Cas:108-59-8
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:liquid Storage:Store in sealed containers at cool & dry plac
Cas:108-59-8
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:108-59-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryDimethyl malonate CAS:108-59-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedi
Cas:108-59-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:108-59-8
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages: I). We have abundant professional production experience. II). We have our own chemical factory. III). Sample is free of charge. IV). Reasonable Price, Excellent Quality & Attentive Service V). Prompt reply: we can reply you
Cas:108-59-8
Min.Order:500 Kilogram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Dimethyl malonate CAS:Dimethyl malonate Specification Items Specifications Appearance Colorless liquid Purity ≧99% Acidity ≤0.07%
Cas:108-59-8
Min.Order:1 Kilogram
FOB Price: $100.0 / 150.0
Type:Other
inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:108-59-8
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:Transparent liquid / Refer to COA Storage:Refer
Cas:108-59-8
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:108-59-8
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Conditions | Yield |
---|---|
With boron trifluoride at 65℃; for 0.333333h; | 100% |
zirconium(IV) oxide; molybdenum at 84.85℃; for 6h; Esterification; | 95% |
iodine for 15h; Heating; | 94% |
Conditions | Yield |
---|---|
With sulfuric acid at 80 - 85℃; for 2h; Neat (no solvent); | 99.8% |
Malonic acid monomethyl ester
methyl chloroformate
A
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 4℃; for 0.5h; | A 95% B n/a |
Malonic acid monomethyl ester
malonic acid dimethyl ester
Conditions | Yield |
---|---|
95% |
Conditions | Yield |
---|---|
With sodium methylate In methanol | 91% |
With sodium hydroxide In methanol | 87% |
N--p-toluolsulfonamid
A
N--p-toluolsulfonamid
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With sodium methylate; malonic acid dimethyl ester In methanol for 8h; Ambient temperature; | A 90% B 84% |
Conditions | Yield |
---|---|
With potassium methanolate In methanol; Co2 (CO)8 | 90% |
Conditions | Yield |
---|---|
With carbon monoxide In methanol Carbonylation at 50 atm.; | A 77% B 7% |
Conditions | Yield |
---|---|
In methanol for 8h; Heating; | A 75% B 73% |
methanol
dichloromethane
carbon monoxide
A
Dimethoxymethane
B
acetic acid methyl ester
C
methyl methoxyacetate
D
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With Methyl formate; sodium methylate; Co2(CO)6{P(C4H9-n)3}2 at 80℃; under 11250.9 Torr; for 15h; electrolysis; | A 8% B n/a C 3% D 74.5% |
With Methyl formate; sodium methylate; Co2(CO)6{P(C4H9-n)3}2 at 80℃; under 11250.9 Torr; for 15h; Product distribution; Mechanism; electrolysis, var. of catalyst, its reduction method, ratio; | A 8% B n/a C 3% D 74.5% |
With sodium hydroxide; carbon-doped cobalt at 80℃; under 23560 Torr; for 1h; | A 1.2 % Chromat. B 7.5 % Chromat. C 1.9 % Chromat. D 28.8 % Chromat. |
(3-hydroxypropyl)hydrazine
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
In methanol for 8h; Heating; | A 74% B 70% |
1-hydrazinyl-2-methylpropan-2-ol
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
In methanol for 8h; Heating; | A 71% B 68% |
4-hydroxybutylhydrazine
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
In methanol for 8h; Heating; | A 69% B 67% |
methanol
malononitrile
A
methyl 2-cyanoacetate
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate for 68h; Heating; | A 68% B 28% |
A
3,3,6,6-tetramethyl-3,3a,6,7-tetrahydro-5H-pyrazolo<5,1-b><1,3>oxazine
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
In methanol for 8h; Heating; | A 67% B 63% |
Conditions | Yield |
---|---|
tetrahexylammonium bromide at 125℃; for 4h; | 67% |
tetrabutylammomium bromide at 125℃; for 5h; | 64% |
tetrabutylammomium bromide at 100℃; for 4h; | 58% |
Conditions | Yield |
---|---|
With Amberlyst 15 at 60℃; for 24h; | 63% |
methanol
cyclohexa-1,4-diene
A
methyl 3,3-dimethoxypropionate
B
malonaldehydebis(dimethylacetal)
C
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With hydrogenchloride; ozone -40 deg C, then ca. 30 min reflux; Yields of byproduct given; | A 60% B n/a C n/a |
With hydrogenchloride; ozone at -40℃; -40 deg C, then ca. 30 min reflux; Yield given; | A 60% B n/a C n/a |
With hydrogenchloride; ozone at -40℃; Product distribution; | A 60% B n/a C n/a |
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 2h; | 54% |
Conditions | Yield |
---|---|
With zinc In tetrahydrofuran 1) 30 deg C, 2 h, 2) reflux, 18 h; | 53% |
carbon monoxide
sodium methylate
bromoacetic acid methyl ester
A
methyl methoxyacetate
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
iron pentacarbonyl In tetrahydrofuran at 55℃; under 3800 Torr; | A n/a B 45% |
dimethyl diazomalonate
cyclopentanone
A
3-(1,1-Bismethoxycarbonylmethyl)cyclopent-1-one
C
1,3-dimethyl 2-(2-oxocyclopentyl)propanedioate
D
malonic acid dimethyl ester
Conditions | Yield |
---|---|
benzophenone for 10h; Irradiation; Further byproducts given; | A 9% B 15% C 39% D 28% |
Conditions | Yield |
---|---|
benzophenone for 14h; Product distribution; Irradiation; | A 31% B 8% C 26% |
for 14h; Irradiation; | A 31% B 8% C 26% |
methanol
1,3-difluoro-1,1,3,3-tetranitropropane
malonic acid dimethyl ester
Conditions | Yield |
---|---|
at 60℃; for 3h; | 30% |
dimethyl diazomalonate
acetone
A
dimethyl 2-hydroxymalonate
B
methyl 2-(methoxycarbonyl)-4-oxopentanonate
C
methyl 2,2-dimethyl-5-oxo-1,3-dioxolane-4-carboxylate
D
malonic acid dimethyl ester
Conditions | Yield |
---|---|
benzophenone for 10h; Irradiation; | A 25% B 5% C 25% D 2% |
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); H2B(μ-3,5-dimethylpyrazole)2BH2 In toluene at 85℃; for 1h; Inert atmosphere; | 25% |
With 5-Hexen-1-ol; C30H26N6Ru(2+)*2Cl(1-); triethylamine In N,N-dimethyl-formamide Inert atmosphere; Irradiation; | |
With 1,2,3,4-tetrakis(carbazol-9-yl)-5,6-dicyanobenzene; triethylamine In 1-methyl-pyrrolidin-2-one at 20℃; for 0.166667h; Inert atmosphere; Irradiation; | 48 %Chromat. |
Conditions | Yield |
---|---|
In ethanol for 2h; UV-irradiation; | 21% |
dimethyl diazomalonate
acetaldehyde
A
dimethyl acetamidomalonate
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
benzophenone for 8h; Irradiation; | A 3% B 15% |
dimethyl diazomalonate
1,2,2-trimethyl-bicyclo{1.1.0}butane
A
1,1-dicarbomethoxy-3,3,4-trimethylpenta-1,4-diene
B
malonic acid dimethyl ester
Conditions | Yield |
---|---|
for 10h; Irradiation; Further byproducts given; | A 14.2% B n/a |
benzaldehyde
malonic acid dimethyl ester
dimethyl 2-benzylidenepropanedioate
Conditions | Yield |
---|---|
With rac-Pro-OH In dimethyl sulfoxide at 20℃; for 16h; Knoevenagel condensation; | 100% |
With piperidine; acetic acid In benzene Knoevenagel Condensation; Dean-Stark; Reflux; Inert atmosphere; | 99% |
With amino-tagged Zr based metal organic frame work(UiO-66-NH-RNH2) In toluene at 23℃; for 2h; Knoevenagel Condensation; | 99% |
2-nitro-benzaldehyde
malonic acid dimethyl ester
dimethyl 2-[(2-nitrophenyl)methylidene]malonate
Conditions | Yield |
---|---|
With piperidine; acetic acid In benzene at 80℃; for 15h; Knoevenagel Condensation; Microwave irradiation; | 100% |
With piperidin-1-ium piperidine-1-carboxylate In neat (no solvent) at 25℃; Knoevenagel Condensation; | 87% |
With potassium carbonate In acetic anhydride at 80℃; for 4h; | 86% |
malonic acid dimethyl ester
dimethyl 2-(hydroxyimino)malonate
Conditions | Yield |
---|---|
With acetic acid; sodium nitrite In water at 0 - 20℃; | 100% |
With acetic acid; sodium hydroxide; sodium nitrite In water at 5 - 20℃; for 24h; | 95% |
With hydrogenchloride; 1-(4-(nitrosooxy)butyl)-3-methylimidazolium chloride; water at 20℃; | 94% |
acrylic acid methyl ester
malonic acid dimethyl ester
trimethyl 4-oxocyclohexane-1,1,3-tricarboxylate
Conditions | Yield |
---|---|
With sodium hydride | 100% |
With sodium methylate In methanol for 1h; Heating; | |
With sodium In methanol; water |
isovaleraldehyde
malonic acid dimethyl ester
dimethyl 2-(3-methylbutylidene)malonate
Conditions | Yield |
---|---|
With chromatorex NH In toluene at 70℃; Reagent/catalyst; Temperature; Knoevenagel Condensation; Flow reactor; Molecular sieve; | 100% |
With L-proline In dimethyl sulfoxide at 20℃; Reagent/catalyst; Knoevenagel Condensation; | 97% |
With rac-Pro-OH In dimethyl sulfoxide at 20℃; for 16h; Knoevenagel condensation; | 92% |
cyclohexenone
malonic acid dimethyl ester
dimethyl 2-(3-oxocyclohexyl)malonate
Conditions | Yield |
---|---|
(anthracenebisresorcinol(4-):2La(3+))polymer In benzene at 20℃; for 48h; Michael addition; | 100% |
at 20℃; for 12h; Michael addition; Electrolysis; | 98% |
Stage #1: malonic acid dimethyl ester at 20℃; Electrolysis; Stage #2: cyclohexenone at 20℃; for 12h; Michael addition; | 98% |
Conditions | Yield |
---|---|
With 4-acetamidobenzenesulfonyl azide; triethylamine In acetonitrile Inert atmosphere; | 100% |
With 4-acetamidobenzenesulfonyl azide; triethylamine In acetonitrile at 20℃; for 24h; Inert atmosphere; | 99% |
With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0 - 20℃; for 1h; | 99% |
benzyl bromide
malonic acid dimethyl ester
2-benzyl-malonic acid dimethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide; toluene at 18℃; for 3h; | 100% |
With sodium hydride In tetrahydrofuran at 20℃; for 2h; | 82% |
Stage #1: malonic acid dimethyl ester With sodium hydride In tetrahydrofuran; paraffin oil at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; paraffin oil at 20℃; for 2h; Inert atmosphere; | 78% |
1-(p-toluenesulfonyl)-1H-imidazole-4(5)-carboxaldehyde
malonic acid dimethyl ester
dimethyl 1(p-toluenesulfonyl)-1H-imidazol-4(5)-ylmethylenemalonate
Conditions | Yield |
---|---|
With piperidine; acetic acid In benzene at 40℃; for 3h; | 100% |
rac-3-acetoxycyclohexene
malonic acid dimethyl ester
dimethyl 2-(cyclohex-2-en-1-yl)malonate
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)nickel (0); N,O-bis-(trimethylsilyl)-acetamide; N,N'-bis(diphenylphosphino)-N,N'-dimethylethane-1,2-diamine In tetrahydrofuran at 20℃; for 0.85h; Product distribution; var. ligand: dppb, var. chiral ligands (R,R)-DIOP, S,S-BPPM, etc.):ee = 5-40percent; | 100% |
With bis(1,5-cyclooctadiene)nickel (0); N,O-bis-(trimethylsilyl)-acetamide; N,N'-bis(diphenylphosphino)-N,N'-dimethylethane-1,2-diamine In tetrahydrofuran at 20℃; for 0.85h; | 100% |
Stage #1: malonic acid dimethyl ester With sodium hydride In tetrahydrofuran at 20℃; for 0.25h; Metallation; Stage #2: rac-3-acetoxycyclohexene With tetrakis(triphenylphosphine) palladium(0); triphenylphosphine In tetrahydrofuran for 4h; Alkylation; deacetoxylation; Heating; | 92% |
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
malonic acid dimethyl ester
(E)-dimethyl (1,3-diphenylprop-2-en-1-yl)propanedioate
Conditions | Yield |
---|---|
With benzenesulfonamide; potassium acetate; [(η3-C3H5)Pd(SC6F4H-4)(P(C6H4OMe-4)3)] In dichloromethane at 20℃; for 4h; | 100% |
With caesium carbonate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; bis(2,6-diisopropylphenyl)imidazolium salt In tetrahydrofuran at 50℃; for 10h; Tsuji-Trost reaction; | 100% |
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 50℃; for 10h; | 100% |
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
malonic acid dimethyl ester
dimethyl 2-[(E)-(S)-1,3-diphenylallyl]-malonate
Conditions | Yield |
---|---|
Stage #1: malonic acid dimethyl ester With 15-crown-5; sodium hydride In acetonitrile at 20℃; for 0.5h; Metallation; Stage #2: rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene; chiral 2-(phosphinoaryl)pyridine palladium In acetonitrile at 0℃; for 1h; Alkylation; | 100% |
With chiral 1-dinaphthoazepino-2-dinaphthophosphepinoethane*BH3; potassium acetate; bis-(trimethylsilyl)acetamide; palladium diacetate In dichloromethane at 20℃; for 6h; | 100% |
With bis(η3-allyl-μ-chloropalladium(II)); C28H36N4O4P2; tetrabutylammomium bromide; potassium carbonate In dichloromethane at 20℃; for 18h; Tsuji-Trost reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 100% |
rac-(E)-1,3-diphenyl-3-acetoxy-prop-1-ene
malonic acid dimethyl ester
(R)-methyl 2-carbomethoxy-3,5-diphenylpent-4-enoate
Conditions | Yield |
---|---|
With 1,2-bis[(R)-dinaphthoazepino]ethane ligand; potassium acetate; bis-(trimethylsilyl)acetamide; [(ν3-allyl)PdCl]2 In dichloromethane at 20℃; for 2h; | 100% |
With bis(η3-allyl-μ-chloropalladium(II)); C2-symmetric chiral P; potassium acetate; bis-(trimethylsilyl)acetamide In dichloromethane for 0.5h; Ambient temperature; | 99% |
With benzenesulfonamide; (C6H13)4N(+); bis(η3-allyl-μ-chloropalladium(II)); (R,S)-phosphinooxazoline In acetonitrile | 99% |
methyl (E)-2-carbomethoxy-2-<(E)-4-chloro-2-butenyl>-8-<(tetrahydro-2H-pyran-2-yl)oxy>-6-octenoate
malonic acid dimethyl ester
methyl (E),(E)-2,7,7-tricarbomethoxy-13-<(tetrahydro-2H-pyran-2-yl)oxy>-4,11-tridecadienoate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide for 1.5h; Heating; | 100% |
methyl 2-carbomethoxy-2-<(Z)-4-chloro-2-butenyl>-8-<(tetrahydro-2H-pyran-2-yl)oxy>-6-octynoate
malonic acid dimethyl ester
methyl (Z)-2,7,7-tricarbomethoxy-13-<(tetrahydro-2H-pyran-2-yl)oxy>-4-tridecen-11-ynoate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide for 1.5h; Heating; | 100% |
2-((Z)-4-Chloro-but-2-enyl)-2-[8-(tetrahydro-pyran-2-yloxy)-oct-6-ynyl]-malonic acid dimethyl ester
malonic acid dimethyl ester
(Z)-2,7-Bis-methoxycarbonyl-2-[8-(tetrahydro-pyran-2-yloxy)-oct-6-ynyl]-oct-4-enedioic acid dimethyl ester
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide for 1.5h; Heating; | 100% |
12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione
malonic acid dimethyl ester
2-((2R,12bS)-12-Benzyl-4-thioxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
With caesium carbonate In tetrahydrofuran at 20℃; for 5h; | 100% |
2,2,2-Trichloro-acetimidic acid 2-cyclopropylidene-ethyl ester
malonic acid dimethyl ester
dimethyl (2-cyclopropylideneethyl)malonate
Conditions | Yield |
---|---|
With sodium hydride; bis(dibenzylideneacetone)-palladium(0); bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran for 18h; Ambient temperature; | 100% |
3-acetoxycyclopent-1-ene
malonic acid dimethyl ester
A
dimethyl (S)-cyclopent-2-enylmalonate
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; potassium acetate; bis(η3-allyl-μ-chloropalladium(II)); (Sp)-1-[(1R)-(1-(5-chloro-3H-isobenzofuran-1-ylideneamino)-ethyl)]-2-(diphenylphosphino)-ferrocene In dichloromethane at 20℃; for 16h; | A n/a B 100% |
With n-butyllithium; (1S,2R,3S,5R)-3-diphenylphosphinopinan-10-oic acid Pd In tetrahydrofuran at 25℃; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With sodium hydride; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran at 20℃; for 0.166667h; Product distribution; other solvent, time and temperature; |
methyl 2-cyanoacetate
malonic acid dimethyl ester
A
dimethyl 1,1-cyclopropanedicarboxylate
B
1-acetylcyclopropanecarboxylic acid methyl ester
Conditions | Yield |
---|---|
With potassium carbonate; 18-crown-6 ether In butanone for 3h; Heating; | A 100% B 75% |
propargyl bromide
malonic acid dimethyl ester
dimethyl 2,2-di(prop-2-ynyl)malonate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; toluene Alkylation; | 100% |
Stage #1: malonic acid dimethyl ester With sodium hydride In dimethyl sulfoxide; mineral oil at 0 - 20℃; for 0.5h; Stage #2: propargyl bromide In tetrahydrofuran; mineral oil at 0 - 20℃; for 1.5h; | 100% |
With sodium hydride In tetrahydrofuran Heating; | 98% |
methallyl acetate
malonic acid dimethyl ester
dimethyl 2,2-di(2-methylallyl)malonate
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)nickel (0); N,O-bis-(trimethylsilyl)-acetamide; 1,3-bis-(diphenylphosphino)propane In tetrahydrofuran at 20℃; for 2h; | 100% |
Conditions | Yield |
---|---|
With 1-butyl-4-aza-1-azoniabicyclo[2.2.2]octane hydroxide at 20℃; for 0.0166667h; Reagent/catalyst; Time; Michael Addition; Green chemistry; | 100% |
With tetrabutylammomium bromide; potassium carbonate In hexane Michael condensation; Reflux; | 92% |
With 1-butyl-3-methylimidazolium hydroxide at 20℃; for 3h; Michael addition; | 82% |
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; sodium acetate; bis(η3-allyl-μ-chloropalladium(II)); (Sp)-1-[(1R)-(1-(5-chloro-3H-isobenzofuran-1-ylideneamino)-ethyl)]-2-(diphenylphosphino)-ferrocene In dichloromethane at 20℃; for 16h; | A 100% B n/a |
With benzenesulfonamide; N-(2-diphenylphosphino)benzyl-3,5-dihydro-4H-dinaphth<2,1-c:1',2'-e>azepine; In dichloromethane for 18h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
With sodium hydride; bis(η3-allyl-μ-chloropalladium(II)) In tetrahydrofuran at 20℃; for 0.0833333h; Product distribution; other solvent, time and temperature; various chiral ligands; |
Conditions | Yield |
---|---|
Stage #1: 2-cycloheptenyl acetate With bis(η3-allyl-μ-chloropalladium(II)); (Sp)-1-[(1R)-(1-(5-chloro-3H-isobenzofuran-1-ylideneamino)-ethyl)]-2-(diphenylphosphanyl)ferrocene In dichloromethane at 20℃; for 0.5h; Inert atmosphere; Stage #2: malonic acid dimethyl ester With N,O-bis-(trimethylsilyl)-acetamide; sodium acetate In dichloromethane at 20℃; for 16h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 100% |
With sodium hydride; bis(η3-allyl-μ-chloropalladium(II)); <1-((4S)-4-tert-butyl-4,5-dihydroo; xazol-2-yl)-2-<(biphenyl-2-yl)phenylphosphanyl>cyclopentadienyl>Mn(CO)3 In N,N-dimethyl-formamide at 0℃; for 1.25h; | 86% |
With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); C40H47O5PSSi2; potassium acetate In dichloromethane at 23℃; for 6h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 86% |
malonic acid dimethyl ester
(2R,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-1,4-bis-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-pyridine
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride In dichloromethane at -78 - -20℃; | 100% |
malonic acid dimethyl ester
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride In dichloromethane at -78 - -20℃; | 100% |
propan-1-ol-3-amine
malonic acid dimethyl ester
N,N'-bis(3-hydroxypropyl)propanediamide
Conditions | Yield |
---|---|
at 160℃; for 1h; | 100% |
Conditions | Yield |
---|---|
With triethylamine In diethyl ether Michael addition; | 100% |
With sodium methylate In methanol for 1h; | 63% |
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