7464-50-8

Basic information

• Product Name: 4-methoxy-N-(2-nitrophenyl)benzamide
• Synonyms: 4-Methoxy-N-(2-nitrophenyl)benzamide; Benzamide, 4-methoxy-N-(2-nitrophenyl)-
• CAS NO: 7464-50-8
• Molecular Formula: C₁₄H₁₂N₂O₄
• Molecular Weight: 272.2561
• Mol File: 7464-50-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 367.2°C at 760 mmHg
• Flash Point: 175.9°C
• Density: 1.333g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 4-methoxy-N-(2-nitrophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N-(2-nitrophenyl)benzamide(7464-50-8)
• EPA Substance Registry System: 4-methoxy-N-(2-nitrophenyl)benzamide(7464-50-8)

Safety Data

• Hazardous Substances Data: 7464-50-8(Hazardous Substances Data)

Upstream product

• 38968-72-8 4-Methoxy-N-phenyl-benzimidoyl chloride 
• 100-07-2 4-methoxy-benzoyl chloride 
• 88-74-4 2-nitro-aniline 
• 3424-93-9 4-methoxyphenylacetamide 
• 15163-59-4 potassium o-nitrobenzoate 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 62-53-3 aniline 
• 100-09-4 4-methoxybenzoic acid 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 109187-01-1 4-methoxy-benzoic acid-(3-bromo-2-nitro-anilide) 
• 103517-57-3 N₁-(4-methoxybenzoyl)-1,2-benzenediamine 
• 219519-50-3 N¹-(3-cyanobenzoyl)-N²-(4-methoxybenzoyl)-1,2-benzenediamine 
• 219519-55-8 N¹-(4-cyanobenzoyl)-N²-(4-methoxybenzoyl)-1,2-benzenediamine 
• 239120-44-6 C₂₂H₁₉N₃O₃S 
• 106321-20-4 3-(4-methoxy-phenyl)-benzo[e][1,2,4]triazine-1-oxide 
• 1270965-91-7 2-{2-[(4-methoxybenzoyl)amino]anilino}-2-oxoethylacetate 

Relevant articles and documents

Route to pyrrolo[1,2-a]quinoxalines via a furan ring opening-pyrrole ring closure sequence

A method was developed for the synthesis of pyrrolo[1,2-a]quinoxalines based on an acid-promoted furan ring opening of readily accessible N-(furan-2-ylmethyl)-2-nitroanilines or their heterocyclic analogues followed by a key reductive Paal-Knorr cyclization of the corresponding nitro-1,4-diketones.

CuSO4-mediated decarboxylative C-N cross-coupling of aromatic carboxylic acids with amides and anilines

CuSO4-mediated decarboxylative C-N cross-coupling of aromatic carboxylic acid with amide has been developed, leading to N-arylamides in modest to excellent yields. Anilines bearing electron-withdrawing substituents could also couple efficiently

Folding Patterns in a Family of Oligoamide Foldamers

A series of small, unsymmetrical pyridine-2,6-dicarboxylamide oligoamide foldamers with varying lengths and substituents at the end groups were synthetized to study their conformational properties and folding patterns. The @-type folding pattern resembled the oxyanion-hole motifs of enzymes, but several alternative folding patterns could also be characterized. Computational studies revealed several alternative conformers of nearly equal stability. These folding patterns differed from each other in their intramolecular hydrogen-bonding patterns and aryl-aryl interactions. In the solid state, the foldamers adopted either the globular @-type fold or the more extended S-type conformers, which were very similar to those foldamers obtained computationally. In some cases, the same foldamer molecule could even crystallize into two different folding patterns, thus confirming that the different folding patterns are very close in energy in spite of their completely different shapes. Finally, the best match for the observed NOE interactions in the liquid state was a conformation that matched the computationally characterized helix-type fold. Erase and refold: Like peptides, oligoamide foldamers fold into a number of different conformers that are very close in energy (see picture, stability energies in kcal mol-1 given in parentheses). By using a combination of computational, single-crystal X-ray diffraction, and NMR spectroscopic studies, these folding patterns have been identified and characterized for a family of seven different foldamers with varying substituents.