7465-92-1

Basic information

• Product Name: N-(2-CHLOROPHENYL)-4-METHOXYBENZAMIDE
• Synonyms: N-(2-CHLOROPHENYL)-4-METHOXYBENZAMIDE
• CAS NO: 7465-92-1
• Molecular Formula: C₁₄H₁₂ClNO₂
• Molecular Weight: 261.7
• Mol File: 7465-92-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 146 °C
• Boiling Point: 324.9°C at 760 mmHg
• Flash Point: 150.3°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 0.000238mmHg at 25°C
• Refractive Index: 1.627
• PKA: 12.71±0.70(Predicted)
• CAS DataBase Reference: N-(2-CHLOROPHENYL)-4-METHOXYBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-CHLOROPHENYL)-4-METHOXYBENZAMIDE(7465-92-1)
• EPA Substance Registry System: N-(2-CHLOROPHENYL)-4-METHOXYBENZAMIDE(7465-92-1)

Safety Data

• Hazardous Substances Data: 7465-92-1(Hazardous Substances Data)

Usage

General Description

N-(2-chlorophenyl)-4-methoxybenzamide is a compound with a chemical structure consisting of a benzene ring with a methoxy group and an amide group attached to it. The chlorophenyl group is also attached to the benzene ring, giving the compound its specific structure. This chemical is commonly used in research and pharmaceutical applications as a building block in the synthesis of various organic compounds. It may also have potential medicinal properties, although further research is needed to determine its specific uses and effects.

InChI:InChI=1/C14H12ClNO2/c1-18-11-8-6-10(7-9-11)14(17)16-13-5-3-2-4-12(13)15/h2-9H,1H3,(H,16,17)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 95-51-2 o-chloroaniline 
• 104-47-2 p-methoxybenzylnitrile 
• 88-73-3 2-Chloronitrobenzene 
• 100-66-3 methoxybenzene 
• 3424-93-9 4-methoxyphenylacetamide 
• 615-41-8 2-iodochlorobenzene 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 

Downstream Products

• 77791-15-2 N-(2-Hydroxy-phenyl)-4-methoxy-benzamidine 
• 838-34-6 2-(p-methoxyphenyl)benzoxazole 
• 1246887-29-5 N-(2-chlorophenyl)-4-methoxybenzothioamide 
• 7465-88-5 4-methoxy-N-phenylbenzamide 

Relevant articles and documents

Pd(OAc)2-catalyzed carbonylative coupling of aryl iodide with ortho-haloamines in water

The carbonylative cross coupling of aryl iodide with ortho-haloaniline to ortho-haloanilide using phosphine-free Pd(OAc)2 catalyst in water as a reaction medium has been studied. The present protocol facilitated the reaction of o-haloanilines with a wide variety of hindered and functionalized aryl iodides, affording good yields of the desired products. The protocol was also extended for the synthesis of benzoxazoles through cyclization of ortho-haloanilide using Cu(acac)2 catalyst. Taylor & Francis Group, LLC.

Iron-catalyzed N-arylations of amides

A method was proposed for iron-catalyzed N-arylation of primary amides and its applicability to the synthesis of N-heterocycles by intramolecular ring closures. The method used a catalyst system of 10 mol % of FeCl3 and 20 mol % of N,N'-dimethylethylenediamine (DMEDA). The study found that secondary amides of N-methylbenzamide and N-benzylbenzamide produce N-arylated products in trace amounts. The method developed an iron-based catalyst system for efficient N-arylations of primary amides with aryl iodides. The study used a sealable tube equipped with a magnetic stir bar charged with amide, or K 3PO4, or K2CO3, or FeCl3. The study used NMR spectroscopic analysis to determine the identity and purity of the products. The method observed that different substituted aryl iodides made a positive impact on the reaction.

Nitrile oxide-BF3 complex as electrophilic moiety towards aromatic systems: Stereospecific synthesis of oximes

Aromatic oximes are obtained stereospecifically by action of nitrile oxide-BF3 complexes on aromatic compounds.