74650-76-3

Basic information

• Product Name: 5-(benzyloxy)-2-chloronicotinonitrile
• Synonyms: 5-(benzyloxy)-2-chloronicotinonitrile
• CAS NO: 74650-76-3
• Molecular Formula: C13H9ClN2O
• Molecular Weight: 244.68
• Mol File: 74650-76-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(benzyloxy)-2-chloronicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-2-chloronicotinonitrile(74650-76-3)
• EPA Substance Registry System: 5-(benzyloxy)-2-chloronicotinonitrile(74650-76-3)

Safety Data

• Hazardous Substances Data: 74650-76-3(Hazardous Substances Data)

Upstream product

• 38186-82-2 6-chloro-5-methylpyridin-3-amine 
• 74650-71-8 2-chloro-5-methoxy-3-pyridinecarboxylic acid 
• 74650-72-9 2-chloro-5-methoxynicotinamide 
• 74650-73-0 2-chloro-3-cyano-5-methoxypyridine 
• 74650-70-7 2-chloro-5-methoxy-3-methylpyridine 
• 54232-03-0 2-chloro-5-hydroxy-3-methylpyridine 
• 100-39-0 benzyl bromide 
• 74650-75-2 2-chloro-5-hydroxynicotinonitrile 

Downstream Products

• 74650-77-4 (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile 
• 74650-78-5 (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile maleate salt 

Relevant articles and documents

2-SUBSTITUTED PROPOXY-3-CYANO-5-HYDROXYPYRIDINES AND USE AS ANTIHYPERTENSIVES

The present application discloses certain 2-substituted propoxy-3-cyano-5-hydroxypyridines. The compounds have pharmaceutical activity e.g. as antihypertensives.

Synthesis of 2-Chloro-5-hydroxynicotinonitrile: The Required Intermediate in the Total Synthesis of a Hydroxylated Metabolite of (S)-2-(3-t-Butylamino-2-hydroxypropoxy)-3-cyanopyridine

A convenient method for the synthesis of 2-chloro-5-hydroxynicotinonitrile (10) via 5-amino-2-chloro-3-methylpyridine (3) is described.Subsequent conversions provided the basic metabolite 2 of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine (1). 1