74650-77-4

Basic information

• Product Name: (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile
• CAS NO: 74650-77-4
• Molecular Weight: 355.437
• Mol File: 74650-77-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile(74650-77-4)
• EPA Substance Registry System: (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile(74650-77-4)

Safety Data

• Hazardous Substances Data: 74650-77-4(Hazardous Substances Data)

Upstream product

• 38186-82-2 6-chloro-5-methylpyridin-3-amine 
• 74650-71-8 2-chloro-5-methoxy-3-pyridinecarboxylic acid 
• 74650-72-9 2-chloro-5-methoxynicotinamide 
• 74650-73-0 2-chloro-3-cyano-5-methoxypyridine 
• 74650-75-2 2-chloro-5-hydroxynicotinonitrile 
• 74650-70-7 2-chloro-5-methoxy-3-methylpyridine 
• 100-39-0 benzyl bromide 
• 54232-03-0 2-chloro-5-hydroxy-3-methylpyridine 
• 194861-99-9 ((2Ξ,5S)-3-tert-butyl-2-phenyl-oxazolidin-5-yl)-methanol 
• 74650-76-3 5-benzyloxy-2-chloronicotinonitrile 

Relevant articles and documents

Synthesis of 2-Chloro-5-hydroxynicotinonitrile: The Required Intermediate in the Total Synthesis of a Hydroxylated Metabolite of (S)-2-(3-t-Butylamino-2-hydroxypropoxy)-3-cyanopyridine

A convenient method for the synthesis of 2-chloro-5-hydroxynicotinonitrile (10) via 5-amino-2-chloro-3-methylpyridine (3) is described.Subsequent conversions provided the basic metabolite 2 of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine (1). 1