7466-55-9 Usage
Description
(3Z)-3-[(4-methoxyphenyl)imino]-2-benzofuran-1(3H)-one, also known as Aldrich-CPRC308923, is a benzofuran derivative with the molecular formula C16H11NO3. It is a chemical compound that has potential pharmaceutical applications and is currently being researched for its various uses in the fields of medicine and biology.
Uses
Used in Pharmaceutical Industry:
(3Z)-3-[(4-methoxyphenyl)imino]-2-benzofuran-1(3H)-one is used as a fluorescent probe for the detection of reactive oxygen species (ROS) in biological systems. This allows for the monitoring and study of ROS, which are important in various biological processes and can be associated with diseases when present at high levels.
Used in Cancer Research and Treatment:
(3Z)-3-[(4-methoxyphenyl)imino]-2-benzofuran-1(3H)-one is used as a histone acetyltransferases (HATs) inhibitor. HATs play a role in the regulation of gene expression, and their inhibition can have implications for the treatment of cancer and other diseases by affecting the epigenetic regulation of cells. (3Z)-3-[(4-methoxyphenyl)imino]-2-benzofuran-1(3H)-one is being studied for its potential to modulate these processes and contribute to therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 7466-55-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,6 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 7466-55:
(6*7)+(5*4)+(4*6)+(3*6)+(2*5)+(1*5)=119
119 % 10 = 9
So 7466-55-9 is a valid CAS Registry Number.
7466-55-9Relevant articles and documents
The cyclisation of substituted phthalanilic acids in acetic acid solution. A kinetic study of substituted N-phenylphthalimide formation
Perry, Christopher J.,Parveen, Zahida
, p. 512 - 521 (2007/10/03)
One novel and ten known substituted 3′- and 4′-phthalanilic acids have been prepared. These have been cyclised to two novel and nine known substituted N-phenylphthalimides by heating with glacial acetic acid. Both phthalanilic acids and imides have been characterised in detail and spectroscopic data are given. The kinetics of cyclisation for phthalanilic acids has been examined in detail, and it has emerged that a complex mechanism is operating. This initially involves a reversible, solvent assisted intramolecular nucleophilic attack by amide nitrogen on the carboxylic acid carbonyl. Clear evidence is seen for a long-lived intermediate as a precursor to imide formation. The observed kinetics are rationalised using a model of rapid pre-equilibration, followed by the slow breakdown of the intermediate to imide. Observed rate constants for pre-equilibration show a well behaved, linear Hammett plot (ρ = -1.1), whereas those for formation of imide do not.
