7554-80-5

Basic information

• Product Name: N-(4-METHOXY-PHENYL)-PHTHALAMIC ACID
• Synonyms: 2-(4-MethoxyphenylcarbaMoyl)benzoic acid, 97%;2-{[(4-Methoxyphenyl)amino]carbonyl}benzoic acid;N-(4-METHOXY-PHENYL)-PHTHALAMIC ACID;TIMTEC-BB SBB006508
• CAS NO: 7554-80-5
• Molecular Formula: C₁₅H₁₃NO₄
• Molecular Weight: 271.27
• Mol File: 7554-80-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-METHOXY-PHENYL)-PHTHALAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-METHOXY-PHENYL)-PHTHALAMIC ACID(7554-80-5)
• EPA Substance Registry System: N-(4-METHOXY-PHENYL)-PHTHALAMIC ACID(7554-80-5)

Safety Data

• Hazardous Substances Data: 7554-80-5(Hazardous Substances Data)

Usage

General Description

N-(4-Methoxy-phenyl)-phthalamide, also known as 4-methoxy-N-(phthaloyl)aniline, is a chemical compound that belongs to the class of phthalamide derivatives. It is a white to off-white solid with the molecular formula C16H13NO4 and a molar mass of 283.28 g/mol. N-(4-METHOXY-PHENYL)-PHTHALAMIC ACID is used in various industries, including pharmaceuticals, as an intermediate in the synthesis of other organic compounds. It possesses certain biological activities and has been studied for its potential pharmacological properties, including its potential as a histone deacetylase inhibitor and anti-inflammatory agent. Additionally, it has been investigated for its potential use in the treatment of cancer and other diseases.

Upstream product

• 85-44-9 phthalic anhydride 
• 104-94-9 4-methoxy-aniline 
• 2142-04-3 2-(4-methoxyphenyl)isoindoline-1,3-dione 

Downstream Products

• 85-44-9 phthalic anhydride 
• 104-94-9 4-methoxy-aniline 
• 2142-04-3 2-(4-methoxyphenyl)isoindoline-1,3-dione 
• 7466-55-9 3-[(4-methoxyphenyl)imino]-1(3H)-isobenzofuran-1-one 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 150772-77-3 C₁₆H₁₅NO₄ 
• 150772-78-4 C₁₇H₁₇NO₄ 
• 108444-19-5 3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one 

Relevant articles and documents

Water mediated, environmentally friendly, step-wise, tandem & one-pot syntheses of 2-(1H-benzo[d]imidazole-2-yl)-N-arylbenzamides

Water mediated and environmentally friendly, step-wise, tandem & one-pot syntheses of 2-(1H-benzo[d]imidazole-2-yl)-N-arylbenzamide derivatives have been developed by simply combining phthalic anhydride, anilines and phenylenediammonium dihydrogenphosphate. This reaction has an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign.

Aza-DielsAlder reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides: Steric effects on reaction outcome

The synthesis of 5-substituted 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)- ones via [4 + 2] imino-DielsAlder cyclization from N-aryl-3- hydroxyisoindolinones and N-vinyl lactams under Lewis acid-catalysed anhydrous conditions is reported. Reactions of N-(2-substituted-aryl)-3- hydroxyisoindolinones with N-vinylpyrrolidone under identical conditions resulted in the formation of 2-(2-substitued-aryl)-3-(2-(2-oxopyrrolidin-1-yl) vinyl)isoindolin-1-one analogues indicating steric hinderance as the cause of deviation. The probable mechanism of the reaction based on the results from X-ray crystallography and molecular modelling is discussed.

Solvent-mediated one-pot synthesis of cyclic N-Substituted imides

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