7467-91-6

Basic information

• Product Name: 6-Hydroxyquinoxaline
• Synonyms: 6-Hydroxyquinoxaline;6-Quinoxalinol;4H-quinoxalin-6-one;quinoxalin-6-ol
• CAS NO: 7467-91-6
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.15
• Mol File: 7467-91-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: >350 °C
• Boiling Point: 257.1 °C at 760 mmHg
• Flash Point: 109.3 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 0.0148mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: 2-8°C
• PKA: 7.54±0.40(Predicted)
• CAS DataBase Reference: 6-Hydroxyquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxyquinoxaline(7467-91-6)
• EPA Substance Registry System: 6-Hydroxyquinoxaline(7467-91-6)

Safety Data

• Hazardous Substances Data: 7467-91-6(Hazardous Substances Data)

Usage

General Description

6-Hydroxyquinoxaline is a chemical compound with the molecular formula C8H6N2O. It is a derivative of quinoxaline and consists of a six-membered aromatic ring fused to a five-membered nitrogen-containing ring, with a hydroxyl group attached to the aromatic ring. 6-Hydroxyquinoxaline is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and organic materials. Its versatile reactivity and potential for substitution at various positions make 6-Hydroxyquinoxaline a valuable precursor in the development of new compounds for a range of industrial applications. Additionally, it exhibits antioxidant and antimicrobial properties, which makes it of interest for potential therapeutic uses.

InChI:InChI=1/C8H6N2O/c11-6-1-2-7-8(5-6)10-4-3-9-7/h1-5,10H

Upstream product

• 6639-82-3 6-methoxyquinoxaline 
• 615-72-5 3,4-diaminophenol 
• 517-21-5 glyoxal sodium bisulfite 
• 577-71-9 3,4-dinitophenol 
• 5448-43-1 6-chloroquinoxaline 
• 50998-17-9 6-bromoquinoxaline 
• 89770-34-3 6-ethoxyquinoxaline 
• 50998-18-0 6-iodoquinoxaline 
• 852432-98-5 (quinoxalin-6-yl)boronic acid 
• 95-83-0 4-Chloro-1,2-phenylenediamine 

Downstream Products

• 7467-92-7 1,4-dioxy-quinoxalin-6-ol 

Relevant articles and documents

Identification of an Oxalamide Ligand for Copper-Catalyzed C?O Couplings from a Pharmaceutical Compound Library

A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that is generally effective for copper-catalyzed C?O cross-couplings to prepare both biarylethers as well as phenols under mild conditions.

A catalytic oxidation fragrant boron class compound preparing phenol method (by machine translation)

The invention discloses a method for catalytic oxidation of phenolic compounds fragrant boron class compound synthesis method, the flux in the solvent in the aqueous solution, under the action of alkali, adding hydrazine hydrate or acid hydrazides catalyst, catalytic oxidation fragrant boron class compound directly for the preparation of phenolic compound. The invention of the method of preparation of the phenol compound, the catalyst is a cheap hydrazine hydrate or hydrazine compound, the oxidizing agent is atmospheric pressure of air or oxygen, the reaction does not need good and activeness metal catalyst, is extensive and stable substrate, substrate-sensitive functional group compatibility good and wide range of application. In the optimized under the reaction conditions, the yield of the target product separation up to 99%. (by machine translation)

Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C-N, C-O, and C-F cross-coupling reactions with a variety of (hetero)arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts, particularly in the case of the bulkiest biarylphosphine ligands, for which palladacycle-based precatalysts do not readily form. The precatalysts described herein are easily prepared and stable to long-term storage under air.