7495-98-9

Basic information

• Product Name: (4-chlorophenyl)(naphthalen-2-yl)methanone
• CAS NO: 7495-98-9
• Molecular Formula: C₁₇H₁₁ClO
• Molecular Weight: 266.7216
• Mol File: 7495-98-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 429.8°C at 760 mmHg
• Flash Point: 236.1°C
• Density: 1.248g/cm³
• Vapor Pressure: 1.36E-07mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: (4-chlorophenyl)(naphthalen-2-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)(naphthalen-2-yl)methanone(7495-98-9)
• EPA Substance Registry System: (4-chlorophenyl)(naphthalen-2-yl)methanone(7495-98-9)

Safety Data

• Hazardous Substances Data: 7495-98-9(Hazardous Substances Data)

Usage

General Description

(4-chlorophenyl)(naphthalen-2-yl)methanone, also known as 4-CNPM, is a chemical compound with the molecular formula C17H11ClO. It is a ketone derivative with a 4-chlorophenyl and naphthalene-2-yl group attached to the carbonyl carbon. 4-CNPM has been used in research as a building block for the synthesis of various organic compounds and pharmaceuticals. It is also known for its potential as a precursor in the production of designer drugs. The compound has been the subject of scientific study to explore its structure-activity relationship and potential bioactivity, particularly in the field of medicinal chemistry. However, given its potential for misuse, 4-CNPM is a regulated substance in many jurisdictions.

Upstream product

• 613-46-7 2-naphthalenecarbonitrile 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 101697-11-4 2-(4-chlorobenzoyl)-1-naphtoic acid 
• 21473-01-8 2-naphthalenylmagnesium bromide 
• 104-88-1 4-chlorobenzaldehyde 
• 32316-92-0 naphthalene-2-boronic acid 
• 122-01-0 4-chloro-benzoyl chloride 
• 790-41-0 4-chlorobenzoic anhydride 
• 5343-99-7 1,2-naphthalenedicarboxylic anhydride 
• 91-20-3 naphthalene 
• 580-13-2 2-bromonaphthalene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 147022-24-0 (4-chlorophenyl)(naphthalene-2-yl)methanol 
• 3042-67-9 2-(4-chlorobenzyl)naphthalene 
• 70557-76-5 2-(4-chlorobenzyl)-1,4-naphthoquinone 
• 147022-12-6 1-[(4-Chloro-phenyl)-naphthalen-2-yl-methyl]-1H-imidazole 

Relevant articles and documents

Beyond the Corey–Chaykovsky Reaction: Synthesis of Unusual Cyclopropanoids via Desymmetrization and Thereof

Desymmetrization-based protocols for the synthesis of highly functionalized indeno-spirocyclopropanes and cyclopropa-fused indanes have been established through unexpected reactions triggered by the Corey–Chaykovsky reagent. These structures were further elaborated in one step to privileged scaffolds such as fluorenones, indenones, and naphthaphenones. For instance, an acid-catalyzed transformation of indeno-spirocyclopropanes provided fluorenones via a homo-Nazarov-type cyclization, and naphthaphenones were obtained via an acid-catalyzed cyclopropane ring-opening/retro-Michael sequence.

Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of Arylboronic Acids and α-Iminonitriles through C–CN Bond Activation

A Pd-catalyzed Suzuki–Miyaura cross-coupling reaction between arylboronic acids and α-iminonitriles has been developed. The reaction proceeds through selective activation of the C–CN bond, tolerates a wide range of substituents, and delivers the versatile ketone products in moderate to excellent yields.

Transition-metal-free, ambient-pressure carbonylative cross-coupling reactions of aryl halides with potassium aryltrifluoroborates

We disclose an unprecedented transition-metal-free carbonylative cross coupling of aryl halides with potassium aryl trifluoroborates even at atmospheric pressure of carbon monoxide. This protocol is efficient, operationally simple, and shows wide scope with regard to both aryl halides and potassium aryl trifluoroborates containing a series of active functional groups.