74963-37-4

Basic information

• Product Name: N-benzyl-2-(methylamino)acetamide
• Synonyms: N-benzyl-2-(methylamino)acetamide
• CAS NO: 74963-37-4
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23096
• Mol File: 74963-37-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-2-(methylamino)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(methylamino)acetamide(74963-37-4)
• EPA Substance Registry System: N-benzyl-2-(methylamino)acetamide(74963-37-4)

Safety Data

• Hazardous Substances Data: 74963-37-4(Hazardous Substances Data)

Upstream product

• 5840-76-6 sarcosine-N-carboxyanhydride 
• 14856-79-2 N-benzyl(trimethylsilyl)amine 
• 124562-34-1 N-(tert-butyloxycarbonyl)sarcosine N'-benzylamide 
• 100-46-9 benzylamine 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 2945-03-1 N-benzyl-2-bromoacetamide 
• 74-89-5 methylamine 
• 107-97-1 sarcosine 

Downstream Products

• 108901-82-2 5-acetyl-3-methyl-4-thio-hydantoic acid benzylamide 
• 4801-77-8 N-benzyloxycarbonyl-N-methyl-glycine benzylamide 
• 64642-23-5 3-benzyl-2-difluoromethyl-1-methyl-2-oxo-2λ⁵-[1,3,2]diazaphospholidin-4-one 
• 64642-21-3 3-benzyl-1-methyl-2-oxo-2-phenyl-2λ⁵-[1,3,2]diazaphospholidin-4-one 
• 64642-22-4 3-benzyl-1-methyl-2-oxo-2-phenoxy-2λ⁵-[1,3,2]diazaphospholidin-4-one 
• 124562-35-2 N-Benzyl-2-[(2,2-diethoxy-ethyl)-methyl-amino]-acetamide 
• 124562-36-3 1-Benzyl-6-hydroxy-4-methyl-piperazin-2-one 
• 124562-37-4 1-Benzyl-4-methyl-6-oxo-piperazine-2-carbonitrile 
• 124562-39-6 1-Benzyl-4-methyl-6-oxo-1,4,5,6-tetrahydro-pyrazine-2-carbonitrile 
• 124562-38-5 4-Benzyl-1-methyl-5-oxo-piperazine-2-carbonitrile 
• 124581-10-8 (2R,3R,5S)-5-Benzylcarbamoyl-2-[3-((S)-1-ethoxycarbonyl-ethoxycarbonyl)-propionyl]-1-methyl-pyrrolidine-3-carboxylic acid (S)-1-ethoxycarbonyl-ethyl ester 
• 124562-42-1 (5R,6S)-3-Benzyl-4-[2-((R)-1-ethoxycarbonyl-ethoxycarbonyl)-eth-(E)-ylidene]-8-methyl-2-oxo-3,8-diaza-bicyclo[3.2.1]octane-6-carboxylic acid (R)-1-ethoxycarbonyl-ethyl ester 
• 124562-42-1 (5R,6R)-3-Benzyl-4-[2-((R)-1-ethoxycarbonyl-ethoxycarbonyl)-eth-(E)-ylidene]-8-methyl-2-oxo-3,8-diaza-bicyclo[3.2.1]octane-6-carboxylic acid (R)-1-ethoxycarbonyl-ethyl ester 

Relevant articles and documents

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts

Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.

Ruthenium-catalysed oxidation of alcohols to amides using a hydrogen acceptor

A wider investigation into the synthesis of secondary amides from primary alcohols using a hydrogen acceptor using commercially available [Ru(p-cymene)Cl2]2 with bis(diphenylphosphino)butane (dppb) as the catalyst. The report looks at over 50 examples with varying functionality and steric bulk, whilst also covering the first reported results using microwave heating to effect the transformation.

Complex Pyrrolidines via a Tandem Michael Reaction/1,3-Dipolar Cycloaddition Sequence. A Novel Method for the Generation of Unsymmetrical Azomethine Ylides

A novel tandem Michael addition/1,3-dipolar cycloaddition protocol for the assembly of the 3,8-diazabicyclooctane ring system found in naphthyridinomycin (1) and quinocarcin (2) is described.